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109 0 0 0 OA Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

著者: Takahashi Kazutoshi Yamanaka Shinya
出版者: Elsevier Inc.
雑誌: Cell (ISSN:00928674)
巻号頁・発行日: vol.126, no.4, pp.663-676, 2006-08-25
被引用文献数: 19928

This article is related to the Nobel Prize in Physiology or Medicine 2012

37 0 0 0 IR Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

著者: TAKAHASHI K
出版者: Elsevier Inc.
雑誌: Cell (ISSN:00928674)
巻号頁・発行日: vol.126, no.4, pp.663-676, 2006-08-25
被引用文献数: 157 19928

This article is related to the Nobel Prize in Physiology or Medicine 2012Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers. Following injection into blastocysts, iPS cells contributed to mouse embryonic development. These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors.

2018-12-21 03:52:11
36 CiteULike
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128 0 0 0 Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

著者: ALTSCHUL S. F.
雑誌: Nucleic Acids Res.
巻号頁・発行日: vol.25, no.17, pp.3389-3402, 1997
被引用文献数: 549 55977

2016-11-30 09:25:36
127 CiteULike
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64 0 0 0 IR Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

著者: Takahashi Kazutoshi Tanabe Koji Ohnuki Mari Narita Megumi Ichisaka Tomoko Tomoda Kiichiro Yamanaka Shinya
出版者: Elsevier B.V.
雑誌: Cell (ISSN:00928674)
巻号頁・発行日: vol.131, no.5, pp.861-872, 2007-11-30
被引用文献数: 207 15752

Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription factors. Here, we demonstrate the generation of iPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc. Human iPS cells were similar to human embryonic stem (ES) cells in morphology, proliferation, surface antigens, gene expression, epigenetic status of pluripotent cell-specific genes, and telomerase activity. Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts.

2018-12-21 03:51:29
26 CiteULike
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42 0 0 0 OA Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

著者: Takahashi Kazutoshi Tanabe Koji Ohnuki Mari Narita Megumi Ichisaka Tomoko Tomoda Kiichiro Yamanaka Shinya
出版者: Elsevier B.V.
雑誌: Cell (ISSN:00928674)
巻号頁・発行日: vol.131, no.5, pp.861-872, 2007-11-30
被引用文献数: 15752

252 0 0 0 Collective dynamics of small-world networks

著者: WATTS D. J.
雑誌: Nature
巻号頁・発行日: vol.393, pp.440-442, 1998
被引用文献数: 265 29714

2017-08-18 12:54:12
251 CiteULike
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3 0 0 0 Calorimetric method for determination of sugars and related substances

著者: DUBOIS M.
雑誌: Anal. Chem.
巻号頁・発行日: vol.28, pp.350-356, 1956
被引用文献数: 658 36942

2017-09-23 20:01:02
2 CiteULike
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66 0 0 0 CLUSTAL W:improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice

著者: THOMPSON J. D.
雑誌: Nucleic Acids Res.
巻号頁・発行日: vol.22, pp.4673-4680, 1994
被引用文献数: 1465 48540

2015-06-17 22:40:23
65 CiteULike
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10 0 0 0 A revised medium for rapid growth and bioassays with tobacco cultures

著者: MURASHIGE T.
雑誌: Physiol. Plant
巻号頁・発行日: vol.15, pp.473-497, 1962
被引用文献数: 1197 43536

2015-04-13 10:08:32
9 CiteULike
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3 0 0 0 OA Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds

著者: Miyaura Norio Suzuki Akira
出版者: American Chemical Society
雑誌: Chemical reviews (ISSN:00092665)
巻号頁・発行日: vol.95, no.7, pp.2457-2483, 1995
被引用文献数: 11192

2021-09-21 22:24:24
2 CiteULike
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1 0 0 0 OA The Coronavirus Disease 2019 (COVID-19) Pandemic

著者: Saira Baloch Mohsin Ali Baloch Tianli Zheng Xiaofang Pei
出版者: Tohoku University Medical Press
雑誌: The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日: vol.250, no.4, pp.271-278, 2020 (Released:2020-04-23)
参考文献数: 19
被引用文献数: 73 230

The present study provides an overview of the coronavirus disease 2019 (COVID-19) outbreak which has rapidly extended globally within a short period. COVID-19 is a highly infectious respiratory disease caused by a new coronavirus known as SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2). SARS-CoV-2 is different from usual coronaviruses responsible for mild sickness such as common cold among human beings. It is crucial to understand the impact and outcome of this pandemic. We therefore overview the changes in the curves of COVID-19 confirmed cases and fatality rate in China and outside of China from 31st of December 2019 to 25th of March 2020. We also aimed to assess the temporal developments and death rate of COVID-19 in China and worldwide. More than 414,179 confirmed cases of COVID-19 have been reported in 197 countries, including 81,848 cases in China and 332,331 outside of China. Furthermore, 18,440 infected patients died from COVID-19 infection; 3,287 cases were from China and 15,153 fatalities were reported worldwide. Among the worldwide infected cases, 113,802 patients have been recovered and discharged from different hospitals. Effective prevention and control measures should be taken to control the disease. The presented Chinese model (protocol) of disease prevention and control could be utilized in order to curb the pandemic situation.

2021-12-30 04:28:13
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18 0 0 0 A flexible new technique for camera calibration

著者: ZHANG Z.
雑誌: TPAMI, 2000
巻号頁・発行日: pp.1330-1334, 2000
被引用文献数: 156 9907 6590

2014-09-03 17:15:38
17 CiteULike
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12 0 0 0 Backpropagation applied to handwritten zip code recognition

著者: LECUN Y.
雑誌: Neural Computation
巻号頁・発行日: vol.1, pp.541-551, 1989
被引用文献数: 33 7157

2018-05-28 20:16:51
11 CiteULike
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19 0 0 0 MEGA4 : Molecular evolutionary genetics analysis (MEGA) software version 4.0

著者: TAMURA K.
雑誌: Mol. Biol. Evol.
巻号頁・発行日: vol.24, pp.1596-1599, 2007
被引用文献数: 260 22902

2016-04-11 02:10:16
18 CiteULike
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2577 0 0 0 OA Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

著者: Jianjun Gao Zhenxue Tian Xu Yang
出版者: International Research and Cooperation Association for Bio & Socio-Sciences Advancement
雑誌: BioScience Trends (ISSN:18817815)
巻号頁・発行日: pp.2020.01047, (Released:2020-02-19)
参考文献数: 7
被引用文献数: 58 1735

The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.