著者
冨山 誠彦 今 智矢 船水 章央 上野 達哉 羽賀 理恵 西嶌 春生 新井 陽 鈴木 千恵子 布村 仁一 馬場 正之
出版者
日本神経治療学会
雑誌
神経治療学 (ISSN:09168443)
巻号頁・発行日
vol.33, no.6, pp.642-645, 2017 (Released:2017-04-30)
参考文献数
10

Istradefyllineはウエアリング・オフのあるParkinson病患者の運動症状を改善する.しかし実臨床ではistradefyllineが有効でないこともしばしばあり,どのような患者にistradefyllineが有用なのか迷うことも多い.そこでウエアリング・オフがあり,オン時の運動症状が軽度なParkinson病患者(オン時のUPDRSパートIIIスコアが15点以下)を対象にistradefylline 20mg/日の有効性をオープンラベル試験にて評価した.14例の患者が8週間の試験を終了できた.Istradefyllineの追加投与により,オン時のUPDRSパートIIIスコアが有意に低下し,オフ時間が有意に短縮した.そのうちの13例は試験終了時にParkinson病症状の改善を自覚しており,istradefyllineの内服継続を希望した.ウエアリング・オフがあり,オン時の運動症状が軽度でドパ反応性が保たれている患者でのistradefyllineの有用性が示唆された.
著者
増澤 高志 南 繁行
出版者
人間環境学研究会
雑誌
人間環境学研究 (ISSN:13485253)
巻号頁・発行日
vol.8, no.1, pp.45-53, 2010 (Released:2010-06-30)
参考文献数
33
被引用文献数
2 5

An electric wheelchair is classified into the joystick type or scooter type in Japan. Especially, an electric wheelchair of the joystick type is one of the indispensable one for the movement of the person with severely physically disabilities. In this paper, the current state in Japan is described about the kind of a law, a standard, and a supply system and an electric wheelchair that is related to an electric wheelchair and markets. In this paper, the current status of the related law, supplier systems, the achievements of technical functions are described.
著者
大塚 豊
出版者
日本比較教育学会
雑誌
比較教育学研究 (ISSN:09166785)
巻号頁・発行日
vol.1992, no.18, pp.53-64,202, 1992-06-25 (Released:2011-01-27)

This paper aims to elucidate the effects and implications for China of higher education and overseas study. For this purpose 1, 333 leaders in various fields who completed higher education and/or studied abroad have been extracted from persons listed in a “Who's Who in China” published by Shanghai Dictionary Publishing Company in 1989, and their school career and professional experiences analyzed.Ragarding schooling within China, 924 people (68.5%) are graduates of ordinary universities and colleges, followed by 204 (15.1%) graduates of some military institutions and 115 (8.5%) graduates of Communist Party schools and cadre training schools. As far as their academic specialities are concerned, those who studied engineering are the most numerous, amounting to 230 (17.2%). In contrast to China's strong image of a “super-gerontocracy”, many leaders are college graduates of the post-liberation era and the rejuvenation of various leaders has gradually been taking place. Generally speaking, what emerges is an image of leaders with knowledge and skills in science and technology, unlike the traditional image of Chinese leaders, who were inclined to be dominated by the literati.What deserves special mention is the fact as many as 309 people (23.2%) have experience of studying abroad. Judging from the country to which they went, there has been a clear “shift of center” according to the period, i.e. from Japan to the US, then from the US to the Soviet Union. Today one can clearly see the outcome of studying in the Soviet Union during the 1950s.Analyzing the professional careers taken up by these leaders and their academic specialities, the largest number have taken administrative or governmental jobs, and economics seems to be considered the most important discipline for a future bureaucrat. There are a few cases of mismatches but most of the bureaucrats with training in technology and agriculture as their academic background have been skilfully allotted to relevant posts. Party schools and cadre schools have played an important role in training those engaged in party-related jobs. Furthermore, among college professors, researchers, engineers, journalists, elementary and secondary school teachers, military personnel and judicial officers, there is also a high degree of coincidence between the academic speciality and subsequent professional career. Thus the effects of planned training and planned job allotment can be clearly recognized. In particular, the degree of coincidence of the administrative content of the work of Ministers and Vice-ministers with their past academic speciality is much higher than in Japan.
著者
Yukiko SHOUJI Chika HASEGAWA Xiao-Pen LEE Masaya FUJISHIRO Takaaki MATSUYAMA Miho YAMADA Ayako KURIKI Yuka KATO Noriko NEMOTO Takeshi KUMAZAWA Shinichi SUZUKI Keizo SATO
出版者
The Showa University Society
雑誌
The Showa University Journal of Medical Sciences (ISSN:09156380)
巻号頁・発行日
vol.30, no.2, pp.175-187, 2018 (Released:2018-08-31)
参考文献数
33
被引用文献数
1

A high-throughput method was developed to analyze five barbiturates (phenobarbital, cyclobarbital, amobarbital, secobarbital, and thiopental) and a metabolite in human body samples using a new Monolithic C18 gel-packed Spin Tip and ultra-performance liquid chromatography (UPLC)-quadrupole-time-of-flight (Q-ToF) mass spectrometry (MS). Plasma (20µl) or urine (100µl) samples spiked with the five barbiturates and 5-(4-methylphenyl)-5-phenylhydantoin (internal standard, IS) were mixed with distilled water. The mixture was extracted using the Monolithic C18 Spin Tip, and the analytes retained on the C18 phase were then eluted with methanol. The eluate was injected directly into an analytical column (Waters Acquity BEH C18, 50mm×2.1mm i.d., particle size 1.7µm), and quantified by Q-ToF-MS with negative-ion electrospray ionization (ESI). Good separation and clear peak shapes of the five drugs were achieved within an analysis time of 6min, including the extraction time. All drugs spiked in the plasma showed recoveries of 86-98%. The regression equations for the five drugs showed excellent linearities in the range of 5-500ng/20µl of plasma, with limits of detection and i-Fit of 1ng/20µl. The method was also successfully applied to determine the level of amobarbital and its metabolite in human plasma and urine, respectively, after oral administration to a volunteer. This new method could be applied widely in the clinical and forensic fields for the quantitative determination of drugs and metabolites.

1 0 0 0 OA 市中取締類集

出版者
巻号頁・発行日
vol.[271] 芝居所替之部,
著者
張 楠 Nan ZHANG
出版者
創価大学日本語日本文学会
雑誌
日本語日本文学 (ISSN:09171762)
巻号頁・発行日
no.23, pp.89-107, 2013-03-20

本論文は『源氏物語』の中に出てくる上巳(三月三日)の行事を取り上げ,中国の歳時文化と道家の文化が重なっている事実で,古代日本の年中行事における道学思想の受容を考察してみた。具体的に三方面から展開する。一, 上巳の祓いと曲水の宴は,道家思想から生まれた行事である。二, 桃に避邪の呪力があるという道教の信仰に支えられて,桃の花は上巳の祓えの花としての位置を確立して行くのであると思われる。三, 桃の女性象徴は,女の子の無邪気と結び付いて,日本の桃の節供(女の節供)になるかもしれないと思われる。
著者
Yusuke KIMURA Takashi HARADA Takafumi SASAKI Tomoko IMAI Noboru MACHIDA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.18-0272, (Released:2018-09-21)
被引用文献数
3

A 10-week-old miniature dachshund presented with acute onset of weakness. Electrocardiography showed sustained ventricular tachycardia, and thoracic and abdominal radiography revealed pleural and peritoneal effusion. Echocardiography revealed severely hypokinetic left and right ventricles. Thoracocentesis and abdominocentesis and subsequent transfer to an oxygen chamber yielded no clinical improvement, and the dog died about 1 hr after admission. Gross examination of a longitudinal section through the entire heart revealed poorly demarcated focal or patchy areas of grayish-white tissue infiltrating extensively into the myocardium. Histologically, these lesions were consistent with infiltrative proliferation of neoplastic lymphoid cells. Immunohistochemical staining confirmed the diagnosis of primary cardiac lymphoma (PCL) of T-cell origin. There have been no previous reports of such young dogs with PCL.

68 0 0 0 OA 独唱:埴生の宿

著者
ビショップ[作曲]
出版者
コロムビア(戦前)
巻号頁・発行日
1932-09
著者
伊藤 高史
出版者
日本マス・コミュニケーション学会
雑誌
マス・コミュニケーション研究 (ISSN:13411306)
巻号頁・発行日
vol.50, pp.140-154,230, 1997-01-31 (Released:2017-10-06)

This paper puts forward a republican view on freedom of expression to discuss the legitimacy of the media's self-regulation of so-called hate speech in Japan. The issues concerning such self-regulation make it evident that the idea of free speech has lost its real meaning and I argue that going back to the idea of republican freedom is indispensable to reconstruct the idea of free expression. By discussing the republican view, I suggest that the problem with the current way of settling the arguments of hate speech is that a third party is eliminated from negotiation processes between the media and complaints.
著者
松永 和風
出版者
コロムビア(戦前)
巻号頁・発行日
1930-10