著者

藤野近昌 編

出版者

藤野近昌

巻号頁・発行日

1917

著者

Shinya Murata Yuzuru Takeuchi Kou Yamanaka Jun Hayakawa Masashige Yoshida Ruriko Yokokawa Akira Wakana Miyuki Sawata Yoshiyuki Tanaka

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.72, no.5, pp.299-305, 2019 (Released:2019-09-19)

参考文献数

30

被引用文献数

3

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Human papillomavirus (HPV)-associated disease is common among men with HPV infection. A quadrivalent HPV (qHPV) vaccine has demonstrated 85.9% efficacy against HPV6/11/16/18-related, persistent (≥ 6 month) infection in a study of Japanese men aged 16–26 years old. Here, we report the results of an open-label study of the immunogenicity and tolerability of the qHPV vaccine (NCT02576054), conducted to bridge findings from Japanese men to Japanese boys aged 9–15 years old. A total of 100 boys completed a three-vaccination regimen (Day 1, and Months 2 and 6), and 99 boys were included in the primary analysis population. The rate of seroconversion at one month after vaccine Dose 3 (Month 7) was high for each type of HPV (anti-HPV6/11/16/18 seroconversion rates [95% CI]: 94.9% [85.5%, 98.3%], 99.0% [94.4%, 100.0%], 99.0% [94.5%, 100.0%], and 99.0% [94.4%, 100.0%], respectively). Moreover, anti-HPV6/11/16/18 geometric mean titers were 482.9 mMU/mL, 1052.8 mMU/mL, 3878.3 mMU/mL, and 1114.5 mMU/mL, respectively. Immune responses to the qHPV vaccine were non-inferior among Japanese boys included in the current study and compared with young Japanese men from a separate study. Injection-site reactions were the most common adverse events, and administration of the vaccine was well tolerated in Japanese boys.

著者

富田 美智江

雑誌

流経法學 = Journal of the Faculty of Law, Ryutsu Keizai University

巻号頁・発行日

vol.17, no.1, pp.1-22, 2017-09-10

著者

加我 君孝

出版者

一般社団法人 日本耳鼻咽喉科学会

雑誌

日本耳鼻咽喉科学会会報 (ISSN:00306622)

巻号頁・発行日

vol.114, no.5, pp.520-523, 2011 (Released:2011-09-10)

参考文献数

3

著者

塚本 昌則

出版者

日本フランス語フランス文学会関東支部

雑誌

日本フランス語フランス文学会関東支部論集 26 (ISSN:09194770)

巻号頁・発行日

pp.61-76, 2017 (Released:2018-12-20)

著者

鮫島 俊哉

出版者

一般社団法人 日本音響学会

雑誌

日本音響学会誌 (ISSN:03694232)

巻号頁・発行日

vol.75, no.7, pp.412-418, 2019-07-01 (Released:2020-01-01)

参考文献数

18

著者

山口 一 伊澤 康一 山田 容子 川上 梨沙 冨岡 一之

出版者

日本建築学会

雑誌

日本建築学会環境系論文集 (ISSN:13480685)

巻号頁・発行日

vol.80, no.716, pp.945-952, 2015 (Released:2015-11-11)

参考文献数

27

被引用文献数

1

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Recently attention has been focused on countermeasures against microorganisms such as viruses and microbe, in connection with pandemics of new forms of influenza or SARS, and the occurrence of bioterrorism. Also, in pharmaceutical or food production facilities, a high standard of internal environment of the facility is required, including countermeasures against microorganisms. These countermeasures from the facility point of view include partitioning of work zones (zoning), and cleaning the air using HEPA filters. However, when workers/researchers are working within a facility, dispersion of dust or adhering microbe brought in from clothes, etc., cause pollution of the air. In this report, the sterilization performance of weak acid hypochlorous solution used as the chemical substance was verified. In addition, the sterilization performance in an actual space varied not only with the chemical substance used, but also with the condition of the room, the air conditioning system, the method of spraying, etc. Therefore, from the above sterilization performance tests using chemical substances, the raw data required for a computational fluid mechanics (CFD) model were derived. A method that enables the effect of the chemical substance to be predicted under various conditions was investigated, and the results are reported.

著者

松本 俊彦

出版者

一般社団法人 日本児童青年精神医学会

雑誌

児童青年精神医学とその近接領域 (ISSN:02890968)

巻号頁・発行日

vol.57, no.3, pp.409-414, 2016 (Released:2019-08-21)

参考文献数

10

著者

岸 玲子 三宅 浩次

出版者

社団法人 日本産業衛生学会

雑誌

産業医学 (ISSN:00471879)

巻号頁・発行日

vol.32, no.1, pp.3-17, 1990 (Released:2009-03-26)

参考文献数

86

---

Neurotoxicity of organic solvents is one of the most important emerging issues in the field of occupational health. Psychological testing has been proven useful not only in clinical diagnosis but also in experimental and epidemiological studies. Although various psychobehavioral performance test batteries have been applied in the study of neurotoxicity of organic solvents during these last two decades among European countries and America, only few studies have been made on these in Japan. It is therefore considered very important to review the major papers published to date, clarify the issues being currently discussed, and propose important studies for future.The present paper provides a review of the results obtained by the application of behavioral performance tests in the study of solvent toxicity. The studies reviewed are classified into the follwoing five parts: 1. psychological test batteries developed to date, 2. human experimental studies and experimental field studies on the acute toxicity of organic solvents, 3. epidemiological studies on industrial workers, 4. characteristics of the central nervous system dysfunction caused by organic solvents, and 5. prognosis of workers diagnosed as chronic organic solvent intoxication. The paper also discusses the applicability of psychobehavioral techniques and addresses issues in data collection in the study of the effects of solvent exposure on the nervous system.

著者

竹内 康浩 西崎 恒男 高城 晋 馬淵 千之

出版者

社団法人 日本産業衛生学会

雑誌

産業医学 (ISSN:00471879)

巻号頁・発行日

vol.14, no.6, pp.563-571, 1972 (Released:2011-03-04)

参考文献数

11

被引用文献数

1 1

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Large amount of organic solvents is used in the processing industries and most of these industries are medium or small enterprises. Therefore, health of workers working there is liable to be disturbed by organic solvents. And as the workers exposed to organic solvents usually complain of indefinite oilments, recently health of workers exposed to organic solvents became to be studied endocrinologically and neurologically.Two workers exposed to organic solvents in a paints industry consulted us and complained of dizziness, headache, tinnitus, insomnia, slight fever, disturbance of appetite, decrease of body weight, cramp of lower extremities, etc. And in our clinical examination, hypofunction of diencephalon-hypohysis-adrenal cortex system, hypesthesia on one side, continuous slight fever, slight orthostatism, abnormal EEG etc. were found and diagnosed as diencephalon syndrome.Working conditions were investigated. This paints industry is medium enterprise but the work room where the two patients were working was small and ventilated not sufficiently. And it was found that the two worker were being exposed to toluene vapor of which concentration ranged from several hundred ppm to one thausand and several hundred ppm and to smaller concentration of other organic solvents. Therefore, it was thought that the disorders of these two patients were caused chiefly by exposure to toluene vapor.The two patients were detached from the work place and treated in our hospital, but disorders of them were not rapidly improved.In view of these serious health disorders of the two workers, we think it is very important that the toxicity of organic solvents should be still more studied especially concerning the effect to the endocrine and nervous systems, and that the working conditions in work place using organic solvents should be still more improved for prevention of organic solvent poisoning.

著者

石黒 勝己

出版者

社団法人 日本写真学会

雑誌

日本写真学会誌 (ISSN:03695662)

巻号頁・発行日

vol.81, no.3, pp.258-262, 2018 (Released:2019-11-28)

参考文献数

10

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春日古墳(奈良県斑鳩町)は,古墳時代後期の豪華な馬具や未盗掘の石棺の発見で著名な藤ノ木古墳に近接する直径約30 mの円墳である.この古墳は位置的にも時期的にも藤ノ木古墳との比較に興味が持たれているが,これまで発掘が行われていないことから,埋葬施設に関して不明であった.今回春日古墳墳丘外部に原子核乾板を検出器として設置しミューオンラジオグラフィーによる内部埋葬施設の検出を試みた.調査結果として,墳丘内部中心方向にミューオン透過量が高く土の厚さが薄い領域があることを検出した.これは,古墳中心部南北方向に奥行き6.1±0.5 mの空洞の存在を示す結果である

著者

難波 精一郎

出版者

日本学士院

雑誌

日本學士院紀要 (ISSN:03880036)

巻号頁・発行日

vol.71, no.2, pp.53, 2017 (Released:2017-02-14)

参考文献数

76

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G. T. Fechner proposed his logarithmic law between physical continuum of stimulus and an attribute of sensation in 1860. Fechner also proposed the distinction between outer and inner-psychophysics. Outer-psychophysics deals with the relation between the observable participant's response and stimulus. In outer-psychophysics, it can be postulated that the response is located on the interval scale when the logarithmic law between stimulus and response is established. In inner-psychophysics, the logarithmic law is established in mind on the assumption that the equality of subjective size of just noticeable difference (jnd). However, it is difficult to verify the equality of jnd using empirical procedures. Bergson strongly criticizes that Fechner's law is based on an assumption that cannot be verified. Zwislocki (1991) defines that the measurement entails matching of common attributes of things or events. According to his definition of “Natural Measurement”, we can match the different things or events on the common psychological continuum. As a result, matching operation can ensure the point of subjective equality (PSE) to be a common attribute among different objects. When an appropriate measure is applied, the same PSE from different things or events confirms the same point on the continuum of common attribute of sensation. The PSE is a physical measure. It can be measured using objective or empirical procedure. An important role of psychophysics is to find an appropriate physical measure. Usually, the standardized physical measure of adequate stimulus is modified on the basis of psychophysical data and reflects the characteristics of sensation. Therefore, a good relationship between subjective response to adequate stimulus and a standardized measure can be expected. It is true that the relation between the loudness judgment of various kinds of nonsteady sounds and a standardized index (e. g. equivalent continuous A-weighted sound pressure level: LAeq) exhibits a high coefficient correlation. However, a law derived from the experimental results depends on the psychophysical method used. For example, the method of category scaling results logarithmic law and magnitude estimation results power law. The result of the experiment using the scale discriminative method was introduced to verify whether the logarithmic law or the power law was valid for the loudness judgment. The results showed that participants' quantitative judgments were well adapted to the experimental procedure. Torgerson (1960) suggests that the participants seem to judge the stimulus taking a different strategy depending on the purpose of the experiment. In daily life situations, we are very adaptive to quantitative behavior for satisfying the purpose of the behavior. This poses a problem of ecological validity in psychophysics. Therefore, it is necessary to select the appropriate stimuli and method to simulate the daily life situations in the psychophysical experiments. Main attributes of auditory sensation are loudness, pitch and timbre. Both loudness and pitch are one dimensional, but timbre or tone quality is multidimensional. It is difficult to constitute rating scale of tone quality expressed by only one physical dimension, and at present, it is far from to establish a general psychophysical rule for applying to tone quality. However, if the sound source is limited, a possibility of establishing a physical scale to predict tone quality. Some examples of the machine sound's tone quality control were introduced.

著者

Eri Kikkawa Masafumi Tanaka Tomi T. Tsuda Koichi Murata Taeko K. Naruse Akinori Kimura

出版者

Japanese Society for Histocompatibility and Immunogenetics

雑誌

日本組織適合性学会誌 (ISSN:21869995)

巻号頁・発行日

vol.26, no.3, pp.195-203, 2019 (Released:2019-12-27)

参考文献数

34

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Endangered penguins are in need of the genetic management to estimate the risk for loss of genetic diversity from populations resulting from habitat fragmentation or inbreeding. However, as for genome diversity in penguin species, there are limited reports and it is insufficient to give useful and appropriate information. In the present study, we obtained the full length sequence of the MHC class II gene, which is expected to be a useful genetic marker for biodiversity in conservation genetics. The 4.4 kb genome region containing two novel genes was determined for nucleotide sequences using genomic DNA extracted from Humboldt penguin, by using the inverse PCR method. Homology analysis of MHC class II genes with those from other birds suggested that the novel two genes were alpha and beta genes. In addition, phylogenetic analysis suggested that the beta gene of penguins was clustered with the beta genes from waterfowl. These observations provide basic information on the structure of MHC class II locus to relieve the genetic diversity of penguin species.

著者

高 兵兵

出版者

国際日本文化研究センター

雑誌

日本研究 : 国際日本文化研究センター紀要 (ISSN:09150900)

巻号頁・発行日

vol.32, pp.83-98, 2006-03-31

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「残菊」は、中国唐代以来詩に詠まれていた題材であるが、日本ではそれをはじめて詩に詠んだのは、菅原道真である。しかも、中国の古典詩では「残菊」はあまり取りあげられなかったのに対して、日本では菅原道真をはじめとする漢詩人たちによって積極的に取りあげられていたようである。

著者

大屋 藍子 槇野 久士 孫 徹 橡谷 真由 玉那覇 民子 大畑 洋子 肥塚 諒 松尾 美紀 河面 恭子 藤井 紀子 金子 春恵 河合 幸枝 福島 佳織 万福 尚紀 細田 公則 武藤 崇

出版者

一般社団法人 日本糖尿病学会

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.62, no.12, pp.748-754, 2019-12-30 (Released:2019-12-30)

参考文献数

19

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本研究は,糖尿病に対する回避の程度とセルフケア行動の関連を確認し,心理的柔軟性のパターンによってセルフケア行動に違いがあるか検討を行うことを目的とした.124名の2型糖尿病患者に対し,糖尿病に対する心理的態度やセルフケア行動の程度について質問紙調査を実施した.その結果,糖尿病に対する回避の程度が高い者は糖尿病に関する心理的負担が高く,情動的摂食や外発的摂食の傾向も高かった.また,階層的クラスター分析を行った結果,行動先行型,非行動型,行動柔軟型の3つのクラスターが生成された.中でも人生の価値が明確でそれに応じた行動がとれるが,不安や思考への適切な対処が難しい「行動先行型」の患者は,日常での運動頻度が高い一方,心理的負担や情動的摂食の程度も高く,心理的問題の存在が示唆された.2型糖尿病患者には心理的状態に応じたセルフケア行動の特徴があり,それを考慮した糖尿病教育が必要であることが示唆された.

著者

竹内 泉

出版者

日本科学哲学会

雑誌

科学哲学 (ISSN:02893428)

巻号頁・発行日

vol.36, no.2, pp.135-150, 2003-12-30 (Released:2009-05-29)

被引用文献数

1

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This work proposes a new semantics named "context semantics", which interprets predicate modal logic in which the modality symbols means logical validity. Although the possible world semantics is the most well-known method for semantics of modal logic, it is not so useful or so essential in studying the predicate modal logic. Especially, the transworld identification always makes serious problem. In order to avoid the problem, we propose the new semantics. Our semantics interprets a formula with finite information. This point is the most essential difference between our semantics and possible world semantics.

著者

宮内 哲

出版者

心理学評論刊行会

雑誌

心理学評論 (ISSN:03861058)

巻号頁・発行日

vol.56, no.3, pp.414-454, 2013 (Released:2018-08-18)

被引用文献数

5

著者

神足祐太郎

出版者

国立国会図書館

雑誌

調査と情報 (ISSN:13492098)

巻号頁・発行日

no.1078, 2020-01-09

著者

大湖彬史

出版者

国立国会図書館

雑誌

調査と情報 (ISSN:13492098)

巻号頁・発行日

no.1077, 2020-01-09

著者

中山 健 柴田 芳彰

出版者

資源地質学会

雑誌

資源地質 (ISSN:09182454)

巻号頁・発行日

vol.65, no.3, pp.133-134, 2015 (Released:2018-08-15)

参考文献数

3