著者

本田 勝亮 稲垣 啓太 大貫 よし子 釋 悦子 中村 みどり 志智 大介

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 = Japanese journal of pharmaceutical health care and sciences (ISSN:1346342X)

巻号頁・発行日

vol.34, no.12, pp.1120-1126, 2008-12-10

参考文献数

16

被引用文献数

1 1

---

We established a reporting system for the use of antimicrobial agents for methicillin resistant Staphylococcus aureus (MRSA) infections in January 2003 to help ensure they are used properly.Then,in October 2005,we set up an infection control team (ICT) to monitor the use of four agents for MRSA infections : vancomycin,teicoplanin,arbekacin and linezolid.Changes in the antimicrobial use densities of the agents,the number of patients receiving them and the therapeutic drug monitoring (TDM) execution rate were investigated for three periods : I : before the reporting system (2002),II : while reporting system was in use (2004),III : during ICT monitoring (2006).<br>There was no significant change in the antimicrobial use densities of the agents for MRSA infection,while the number of patients receiving them decreased significantly in period III (p<0.05).Also in period III,the antimicrobial use density of teicoplanin increased significantly (p<0.05),there was a marked decrease in the number of patients receiving vancomycin (p<0.01)and the TDM execution rate increased significantly (p<0.01).<br>The systematic activities performed by the ICT were effective in ensuring the proper use of antimicrobial agents for MRSA infection.Further,by enabling us to share information with other medical staff and conduct rapid interventions,they have been playing an important role in infection control in our hospital.

著者

志智 大介 谷澤 朋美 本田 勝亮

出版者

社団法人 日本感染症学会

雑誌

感染症学雑誌 (ISSN:03875911)

巻号頁・発行日

vol.82, no.4, pp.335-340, 2008-07-20 (Released:2011-02-07)

参考文献数

19

被引用文献数

2 3

---

2001年から2007年までの7年間において静岡県浜松市保健所へのつつが虫病の届出数は6件あった. 内5件について診療録上の考察を行った. 血清抗体価検査上, 4例でもっとも優位に上昇した株はGilliam株だったが, Kawasaki株まで調べた1例ではKawasaki株がもっとも優勢だった. 臨床症状では, 発熱, 発疹, 頭痛, 比較的徐脈を高率にみとめた. 臨床検査では3例に異型リンパ球出現, 全例に好酸球消失を認めた. 4例 (80%) に低ナトリウム血症を認めた. 1例は不適切ADH分泌症候群が疑われた. 全例がminocycline投与で36時間以内に迅速に解熱した.