著者
Osamu Matsuoka Mugen Ujiie Hitoshi Kikuchi Sachiko Otake Danaya Chansinghakul Takahiro Inoue Kucku Varghese Nuchra Sirisuphmitr Tomoyuki Hashiguchi Betzana Zambrano Takahiro Nakama Carina Frago Emilia Jordanov Mandeep Singh Dhingra
出版者
National Institute of Infectious Diseases
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2022.272, (Released:2023-01-31)
参考文献数
33

MenACYW-TT is a quadrivalent meningococcal tetanus toxoid-conjugate vaccine designed to prevent invasive meningococcal disease. The primary objective of this study was to demonstrate non-inferiority of the vaccine seroresponse to a single dose of MenACYW-TT compared to a licensed Meningococcal quadrivalent diphtheria-conjugate vaccine, MCV4-DT. This Phase III double-blind, multi-center study was conducted in meningococcal vaccine-naive participants aged 2-55 years in Japan (NCT04368429; JapicCTI-205288). Participants were randomized 1:1 to MenACYW-TT (n=180) or MCV4-DT (n=180). Functional antibodies against meningococcal serogroups A, C, W, and Y were measured using a serum bactericidal antibody assay with human complement (hSBA) at baseline (D0) and 30 days after vaccination (D30). Seroresponse was defined as post-vaccination titers ≥1:16 for participants with baseline titers <1:8; or ≥4-fold increase for participants with baseline titers ≥1:8. Safety data were collected for 30 days. Non-inferiority of the vaccine seroresponse vs MCV4-DT was demonstrated at D30 for each serogroup (A: 85.6% vs. 65.4%; C: 96.6% vs. 62.6%; W: 87.4% vs. 49.2%; Y: 97.7% vs. 63.5%, respectively). MenACYW-TT was well-tolerated, with no safety concerns identified. In conclusion, when administered as a single dose, MenACYW-TT was well tolerated with a non-inferior immune response compared to MCV4-DT, providing a potential alternative vaccine for this population.
著者
野際 大介 佐藤 栄作
出版者
日本行動計量学会
雑誌
行動計量学 (ISSN:03855481)
巻号頁・発行日
vol.49, no.1, pp.3-13, 2022 (Released:2022-11-10)
参考文献数
29

In recent years, more and more consumers who cancelled their newspaper subscription have signed up for online-flyer portal sites. However, their site access logs are not necessarily linked with their purchase records stored in ID-POS data, which is a marketing problem from the sellers' point of view. As a solution to this problem, we propose a practical framework of a hidden Markov model which allows for the assessment of the flyer advertisement. We also present a hierarchical Bayesian model which sheds light on the information search and shopping behavior of consumers, given individual heterogeneity. Our results demonstrate that the subscribers of online flyers are more likely to visit stores as they have more flyer accesses, email advertisements from portal sites and the announcements of time-limited sales.
著者
坂西 友秀
出版者
埼玉大学教育学部
雑誌
埼玉大学紀要. 教育学部. 教育科学 = Journal of Saitama Univerity. Faculty of Education. Science of Education (ISSN:03879321)
巻号頁・発行日
vol.51, no.2, pp.73-95, 2002

We conducted research on the interactions and relations between Japan and European countries from the 16th to 18th centuries by analyzing diaries, old writings, and old manuscripts with the following perspectives:1. The Japanese perspective on both Westerners and Blacks before National Isolation.2. The Japanese perspective on Blacks before National Isolation.3. The Japanese perspective on both Westerners and Blacks during the Era of National Isolation. Shogun Toyotomi Hideyoshi was very surprised and delighted to see the gorgeous parade of missionaries who were sent to Japan by the vice president oflndia in 1590 as the Portuguese delegation. In the late 16th Century, the Shogun banished foreign missionaries in order to eliminate their work in Japan, but he continued trade between Japan and Portugal. In general, foreign people who stayed in Japan in the 16th and 17th centuries tended to give a poor impression to Japanese citizens. The Japanese watched them everywhere as they were very different from the Japanese. They looked strange to the Japanese, spat even in the houses, walked in the houses with their boots on, ate beef, and did many other things that appeared strange to the Japanese. Most Japanese considered Westerners to be ill mannered and prudish because much of their conduct conflicted with Japanese culture. People living in Nagasaki, which was one of the most important port towns at that time, feared the foreign traders would buy Japanese women and children to sell as slaves to other Asian and Western countries. Blacks were regarded as slaves, and looked down on as inferior people by the Japanese. The people of the port town might already have had ethnic stereotypes toward Blacks in the 16th century. It was not until the end of the Edo era that problems concerning trade, military, and foreign affairs become important psycho-historical background factors influencing relations between Japanese and Westerners.
著者
北田 暁大
出版者
The Japan Sociological Society
雑誌
社会学評論 (ISSN:00215414)
巻号頁・発行日
vol.49, no.4, pp.635-650, 1999-03-30 (Released:2010-11-19)
参考文献数
40

われわれはごく日常的なコミュニケーションの場面において, 他者の行為を記述することによりその行為をその行為者へと帰属させ, 「責任」の所在を指示しているといえようが, そうしたなかで, 行為者の意図 (目的) とは齟齬をきたすような行為記述がしばしば「適切」であるとされることも少なくない。行為者自身が自らの行為の記述に関する「権威」でありえない状況のなかで, われわれはいかにして行為記述の適切性を見定め, また行為の責任を帰属させているのであろうか。本稿では, こうした行為の同定 (identification) や帰責 (attribution) のメカニズムをめぐる問題に照準しつつ, A.Schutzの提示した理由動機/目的動機の概念的区別を導きの糸として, 「行為を解釈すること」と「行為 (者) の責任を問うこと」がどのような関係にあるのかをまずI・II節で分析し, 行為者責任 (行為と行為者の関係) と行為の責任 (行為とその結果の関係) との相違を明らかにする。そして次に, N.Luhmannの「道徳」についての知見を参照しながら, 道徳コミュニケーションにおいて問われる責任が, 行為者責任/行為の責任のいずれとも異なる位相にあることを示し, そのようにして捉えられた道徳が現代社会において孕んでいる両義的な性格をIII節において論じていく。「責任」や「道徳」の社会学 (コミュニケーション論) 的な位置づけを与えることが, 本稿全体を通しての目的である。
著者
佐々木 昭 佐藤 和郎 George L. Cumming
出版者
The Society of Resource Geology
雑誌
鉱山地質 (ISSN:00265209)
巻号頁・発行日
vol.32, no.176, pp.457-474, 1982-12-15 (Released:2009-06-12)
参考文献数
48

The metallic mineralization in the Japanese islands can be divided into three groups in view of the ore lead isotope systematics.(1) The Paleozoic to Mesozoic stratiform (Besshi-type) mineralization is composed of cupriferous iron sulfide ores in which lead is usually a minor constituent (to the level of 10 1-10 2 ppm). The leads are isotopically variable, being consistently low in both 207Pb/ 204Pb and 208Pb/ 208Pb ratios as compared to the lead in the "major (conformable) lead orebodies" of similar ages.(2) The pre-Neogene mineralization excluding the Besshi-type deposits is mostly related to Cretaceous to Paleogene granitoids. Galena is fairly common and forms sizable orebodies in a few skarn-type deposits. Lead isotopic composition is more or less variable regionally, and even locally in some cases, all being, however, low in 206Pb/ 204Pb and high in 208Pb/ 204Pb ratio in comparison with the conformable ore leads.(3) The Neogene mineralization is represented by the kuroko-and related vein-type mineralization of middle Miocene age, carrying abundant lead as one of the major ore metals. The leads are isotopically rather uniform with consistently low 206Pb/ 204Pb and high 208Pb/ 204Pb ratio as compared to the major lead ore system; 43 samples from 30 localities give average 208Pb/ 204Pb 207Pb/ 204Pb and 208Pb/ 204Pb ratios of 18.471±. 108 (2σ), 15.609±.036, and 38.677±.220, respectively. A remarkably consistent isotopic composition close to this average is observed in the kuroko ores from an extensive area of northeast Japan.The Besshi-type ore leads except for those of the Mesozoic Taro deposit show an isotopic pattern similar to that of the ocean volcanic leads, strongly suggesting that the major evolutionary environment of these leads has been in the oceanic mantle. The Taro leads show isotopic features close to the major lead ore system and, in this respect, are unique among Japanese ore leads.The leads of the pre-Neogene and Neogene mineralizations may be identified as crustal lead with respect to their main evolutionary environments. The 207Pb/ 204Pb and 208Pb/ 204Pb ratios of the pre-Neogene leads exhibit a trend in which the relatively high values of these ratios occur in the area where the related granitoids have relatively high initial 87Sr/86Srr ratios; some Neogene leads seem to follow the same trend. The presence of a relatively old and thick continental crust in the source region of these leads can be deduced.The available isotopic data for the oceanic sediment lead occurring closer to the Japanese islands (samples near the Mariana volcanic arc and those from the Ryukyu Trench) apparently deviate from the major spectrum of the Pacific sediments data and plot closer to the data for the Japanese Neogene and pre-Neogene ore leads which may approximate the average of Japanese crustal leads. A relatively 208Pb-impoverished and 208Pb-enriched character indicates that the crustal lead around the Japanese islands has been strongly influenced by the lead evolved in the lower continental crust.
著者
Liqin Sun Jiaye Liu Fang Zhao Jun Chen Hongzhou Lu
出版者
International Research and Cooperation Association for Bio & Socio-Sciences Advancement
雑誌
BioScience Trends (ISSN:18817815)
巻号頁・発行日
pp.2023.01009, (Released:2023-01-22)
参考文献数
9

The tendency of the Omicron variant to rapidly became the dominant SARS-CoV-2 strain and its weaker virulence than other strains worldwide has prompted many countries to adjust their public health strategies. This work summarizes all appropriate clinical interventions to reduce the public health burden caused by COVID-19 according to guidelines from the World Health Organization and 10 countries, i.e., the United States of America (USA), India, France, Germany, Brazil, South Korea, Japan, Italy, the United Kingdom (UK), and China. Five stages of COVID-19 were identified: asymptomatic infection and mild, moderate, severe, and critical illness. Most guidelines recommend antivirals starting with mild cases for those from Germany and India. Since more drugs are being developed and are becoming available to COVID-19 patients, guidelines are increasingly being updated with new pharmacological intervention strategies. Thus, a global view needs to be adopted to provide helpful options and precise treatment strategies during the lasting fight against the COVID-19 pandemic.
著者
秋山 弘之
出版者
日本蘚苔類学会
雑誌
蘚苔類研究 (ISSN:13430254)
巻号頁・発行日
vol.10, no.11, pp.367-368, 2013 (Released:2018-07-03)

One of conspicuous new commers for aquarium plants in mosses known as "Queen Moss" or "Amblystegiaceae sp. Manaus" was revealed to be Hydropogonella gymnostoma.
著者
坂本 健太郎 青木 かがり
出版者
東京大学
雑誌
挑戦的研究(萌芽)
巻号頁・発行日
2020-07-30

鯨類の潜水能力は哺乳類の中で最大である。潜水中には、心拍数を低下させるなど、何らかの循環器系の調節を行う事で、このような長期間の潜水を可能にしていると考えられている。これまでは水中で遊泳する鯨類の心機能を経時的に計測することが出来なかったため、その生理機能は謎に包まれていた。本研究では潜水を行う鯨類から長期間にわたって心電図計測を行い、鯨類の潜水能力を循環器系制御の側面から解明することを目指す。
著者
村本 和世
出版者
日本顎口腔機能学会
雑誌
日本顎口腔機能学会雑誌 (ISSN:13409085)
巻号頁・発行日
vol.23, no.1, pp.1-9, 2016 (Released:2017-03-17)
参考文献数
38

我々は食物を摂取するとき,多くの感覚を駆使して,食べ物の情報として統合している.この情報取得は,本来食物を識別し,摂取の可否を判断するために進化してきたと考えられるが,ヒトにおいて単なる摂食可否の分析から,美味しさを楽しむという別の情報処理が加わってきた.美味しさの基本となる情報,“風味”は食物の味だけでなくにおいや舌触りのような食感をも加えた総合感覚であり,特に味覚と嗅覚との感覚間相互作用が風味形成では重要となる.しかし,風味形成の脳内情報処理機構や感覚間相互作用が行われている脳領域については未だはっきりとはしていない.本稿では,風味の構成要素として重要な味覚と嗅覚の役割,受容機構,伝導経路,脳内情報処理機構などについて簡単に解説する.さらに,風味形成における“島皮質”の役割についての我々の研究の一端を紹介し,食に関する感覚・風味について考察してみたい.
著者
前田 章光 安藤 仁 浅井 徹 石黒 久晶 梅本 紀夫 志水 清和 伊藤 基博 細畑 圭子 牛島 健太郎 藤村 昭夫
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.37, no.8, pp.481-485, 2011 (Released:2012-08-30)
参考文献数
10

Recent studies carried out in Western countries have suggested a potential adverse interaction between clopidogrel and proton pump inhibitors (PPIs), which inhibit CYP2C19 activity. The purpose of this study was to examine the influence of individual PPIs and CYP2C19 polymorphism on the antiplatelet effect of clopidogrel in Japan. The platelet aggregations induced by 20 μmol/L ADP and CYP2C19 single nucleotide polymorphisms (*2 and *3) were determined in 118 patients on aspirin plus clopidogrel (75 mg/day) therapy. Twenty-five and 13 patients were treated with lansoprazole and rabeprazole, respectively. The platelet aggregation of extensive metabolizers (EM : *1/*1) treated with lansoprazole tended to be higher than those not given a PPI (21.5 % vs. 17.4 %, respectively, p=0.14). Lansoprazole was observed to have no effect on platelet aggregation in intermediate metabolizers (IM : *1/*2 and *1/*3) and poor metabolizers (PM : *2/*2, *2/*3, and *3/*3). Furthermore, platelet aggregation in IMs and PMs not given lansoprazole was significantly higher than that in EMs taking lansoprazole. Rabeprazole did not affect platelet aggregation in any genotype. These results suggest that the influence of PPIs on the antiplatelet effect of clopidogrel is minimal in Japanese patients.
著者
大竹 豊
出版者
公益社団法人 精密工学会
雑誌
精密工学会誌 (ISSN:09120289)
巻号頁・発行日
vol.86, no.5, pp.328-333, 2020-05-05 (Released:2020-05-05)
参考文献数
6
被引用文献数
1
著者
市倉 加奈子 日野 亜弥子 田上 明日香 井村 里穂 石田 陽菜 深瀬 裕子 村山 憲男 村瀬 華子 島津 明人 平井 啓 田ヶ谷 浩邦
出版者
公益社団法人 日本心理学会
雑誌
心理学研究 (ISSN:00215236)
巻号頁・発行日
pp.94.21046, (Released:2023-02-01)
参考文献数
39

Workplace changes, such as remote work during the COVID-19 pandemic, have caused serious psychological distress for workers. The aim of this study was to examine job stressors and coping strategies among Japanese workers during the pandemic. The study was a qualitative methods approach using a web-based survey for Japanese workers in May 2020. We asked about job stressors and coping strategies with free text comments. We performed context analysis and categorized job stressors and coping strategies. Of the participants, 59.2 % suffered psychological stress from workplace changes during the pandemic. We identified 11 categories of job stressors including “work-life balance,” “lack of communication,” “overwork,” and “diminishing work role.” We also identified 16 categories of coping strategies including “distraction,” “dealing with work tasks,” “looking for ways to communicate,” “environmental coordination of work-at-home,” “online chatting,” and “psychological disengagement.” This study shows that Japanese workers tried many ways to manage their job stressors under the burden of the state of emergency. In the future, we should examine the association between coping strategies and psychological distress during the COVID-19 pandemic.
著者
三間 大典
出版者
西日本整形・災害外科学会
雑誌
整形外科と災害外科 (ISSN:00371033)
巻号頁・発行日
vol.70, no.2, pp.319-322, 2021-03-25 (Released:2021-04-30)
参考文献数
8

小児急リンパ性白血病(ALL)では発熱,出血,疲労感などが一般的な症状である.今回,小児が多発骨・関節痛を主訴に整形外科を受診し急性リンパ白血病と診断した2例を経験したので報告する.
著者
Siméon Capy Gentiane Venture Pongsathorn Raksincharoensak
出版者
Society of Automotive Engineers of Japan, INC
雑誌
International Journal of Automotive Engineering (ISSN:21850984)
巻号頁・発行日
vol.14, no.1, pp.10-19, 2023 (Released:2023-01-31)
参考文献数
66

ABSTRACT: This article provides a systematic review of research articles on pedestrians and cyclists’ intention recognition to be integrated into autonomous vehicles, especially for decision making and motion planning. We firstly describe why the intention recognition of pedestrians and cyclists is suitable and necessary for autonomous vehicles and why they cannot only rely on traffic regulation laws. Then, we summarise, amongst others, the methodology and sensors used by eighteen peerreviewed research articles published in relevant conferences and journals. We performed a systematic review of articles of the last 10 years from the following databases: IEEE Xplore, Science Direct, ACM digital library, Springer Link, MDPI and Web of Science. We observe from the collected articles that most of them are relying on several sensors, with a predominance including video. They mostly try to obtain the probability of crossing or the trajectory of the pedestrian/cyclist, mostly using a Recurrent Neural Network. In addition to their algorithmic contribution, 4 studies also provide a dataset. We conclude this article by talking about the remaining open challenges.