- 著者
-
Matsuo Yoshinori
- 出版者
- The Genetics Society of Japan
- 雑誌
- Genes & genetic systems (ISSN:13417568)
- 巻号頁・発行日
- vol.78, no.4, pp.309-318, 2003-08-25
- 被引用文献数
-
7
The molecular evolution of the histone multigene family was studied by cloning and determining the nucleotide sequences of the histone 3 genes in seven <i>Drosophila</i> species, <i>D. takahashii, D. lutescens, D. ficusphila, D. persimilis, D.pseudoobscura, D. americana</i> and <i>D. immigrans</i>. CT repeats, a TATA box and an AGTG motif in the 5' region, and a hairpin loop and purine-rich motifs (CAA(T/G)GAGA) in the 3' region were conserved even in distantly related species. In <i>D. hydei</i> and <i>D.americana,</i> the GC content at the third codon position in the protein coding region was relatively low (49% and 45%), while in <i>D. takahashii</i> and <i>D. lutescens</i> it was relatively high (64% and 65%). The non- significant correlation between the GC contents in the 3' region and at the third codon position as well as the evidence of less constraint in the 3' region suggested that mutational bias may not be the major mechanism responsible for the biased nucleotide change at the third codon position or for codon usage bias.<br>