- 著者
- 瀬川 純 数野 憲二 松岡 正人 網本 功 尾崎 正邦 松田 真人 冨井 由文 北野 正彦 黄瀬 正博
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.43, no.7, pp.1238-1240, 1995-07-15 (Released:2008-03-31)
- 参考文献数
- 13
- 被引用文献数
- 3 7
Optically active isomers of 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1, 3]thiazeto[3, 2-a]quinoline-3-carboxylic acid (NM394, 3) were prepared through optical resolution of their racemic intermediate (±)-1 by high-performance liquid chromatography (HPLC). The absolute configuration at the C-1 position in the thiazetoquinolone ring of (-)-3 was confirmed by X-ray analysis of (-)-4 to be S. The in vitro antibacterial activity of (-)-3 was 2-8 times that of (+)-3.