著者

KAWASAKI Tsuneomi UCHIDA Mizuki KAIMORI Yoshiyasu SASAGAWA Taisuke MATSUMOTO Arimasa SOAI Kenso

出版者

The Chemical Society of Japan

雑誌

Chemistry letters (ISSN:03667022)

巻号頁・発行日

vol.42, no.7, pp.711-713, 2013-07-05

参考文献数

44

被引用文献数

22

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5-Pyrimidyl alkanol with an enantiomeric excess of up to >99.5% was formed using chiral crystals of achiral tris(2-hydroxyethyl) 1,3,5-benzenetricarboxylate as a chiral initiator. In the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde, the helicity of the molecular arrangement of achiral tricarboxylate in the crystalline state could be successfully used as a source of chirality to afford enantioenriched alkanol in conjunction with asymmetric autocatalysis with amplification of enantiomeric excess.