In order to validate Total Body Score (TBS) as an index for comprehensive evaluation of human body, we examined relationships between TBS and parameters which are correlated with metabolic syndrome (MS). Receiver operating characteristic (ROC) curve analysis showed that TBS is a useful index for MS screening. TBS had statistically significant correlations with systolic blood pressure, diastolic blood pressure, neutral fat, HDL cholesterol, visceral fat, and subcutaneous fat. The subjects who had low TBS showed statistically high probability to have one or more MS risk factors. The result suggested that assessment with cross-sectional biomedical data is useful for screening of MS risks.