著者

百溪 三郎

出版者

財団法人 日本消化器病学会

雑誌

日本消化機病學會雜誌 (ISSN:04466586)

巻号頁・発行日

vol.51, no.11, pp.439-445, 1954

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Many authors have reported on the change of liver catalase activity in relation to the growth of malignant tumors in the host and to the administration of drugs or substances extracted from cancer tissues.The author found that extracts from a placenta can cause reduction of liver catalase activity in mice when injected intraperitoneally.In the experiments, seasonal fluctuations of the liver catalase activity were also observed. This fact, is important in the research of liver catalase activity.<BR>In the experiments reported in this paper, liver catalase activity was measured periodically. With intention to investigate the productino, transportation, storage and consumption of catalase in the body, catalase activity of blood and brain were also measured periodically.<BR>1) There are seasonal fluctuations in liver, blood, and brain catalase activity.Liver and blood catalase activity has stable periods in summer and winter, and unstable periods in spring and autumn. The values of liver catalase activity are higher in summer, and those of blood are higher in winter contrary to that of liver. No stable period was found in brain catalase activity and their values are higher in summer similarly to that of liver.<BR>2) In following up their correlative relations, marked nagative correlations were found at certain time in the unstable period of the liver catalase activity.<BR>3) In summing up the correlative coefficients, negative correlations were dominant between blood and liver, and posititve correlations were dominant in other cases. This fact proved to be statistically significant.