著者

Takeuchi Setsuo Yonehara Hiroshi Umezawa Hamao

出版者

公益財団法人 日本感染症医薬品協会

雑誌

The Journal of Antibiotics, Series A (ISSN:03681173)

巻号頁・発行日

vol.12, no.5, pp.195-200, 1959

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<p>In the antibiotic screening studies directed by Prof. Sumiki, an antifungal substance was found in a culture filtrate of a fungus, No. K-5201, which was isolated from a soil collected at Karuizawa, Nagano Prefecture. The cultural characteristics of the strain No. K-5201 were investigated by Abe and others¹⁾. The strain was designated as <i>Paecilomyces varioti</i> Bainier var. <i>antibioticus</i>, and the antibiotic produced by this strain was named variotin.</p><p>Variotin is a new antifungal antibiotic, having low toxicity and exhibiting inhibition against <i>Trichophyton</i> and other pathogenic fungi. This paper describes processes of production, extraction and purification of variotin and its properties.</p>