著者
TAKAHASHI K
雑誌
Cell (ISSN:00928674)
巻号頁・発行日
vol.126, no.4, pp.663-676, 2006-08-25
被引用数
157 or 0

This article is related to the Nobel Prize in Physiology or Medicine 2012Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers. Following injection into blastocysts, iPS cells contributed to mouse embryonic development. These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors.

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外部データベース (DOI)

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[nobelprize][science]
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[cell-differentiation]
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[genetic_reprogramming]
[cells][fibroblasts][ipsc][mouse][pluripotent_stem_cells][stem][yamanaka]
[cells][fibroblasts][reprogramming]
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[cells][fibroblast][mouse][stem]
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[2collab][c-myc][cell][connotea][differentiation][embryonic][esc][klf4][mef][oct4][reprogramming][sox2][stem]
[reprogramming][stem_cell]
[cbp][fbl][klf][myc][p300]

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(山中伸弥先生のノーベル賞 key publicationの論文情報 CiNii にあり本文にリンクもされてるのに引用情報だけからの書誌なので山中先生の名前が入ってない。これは残念。) http://t.co/uZOnXTs0

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http://ci.nii.ac.jp/naid/80018983952 (36)