著者

松岡 由香里 大崎 修司 仲村 英也 綿野 哲

出版者

一般社団法人 粉体工学会

雑誌

粉体工学会誌 (ISSN:03866157)

巻号頁・発行日

vol.58, no.8, pp.414-423, 2021-08-10 (Released:2021-10-13)

参考文献数

26

被引用文献数

4

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In this study, a neural network (NN) was applied to a continuous manufacturing process of tablets to predict the tablet physical properties based on a twin-screw granulation operating conditions and tableting pressure. The hyperparameters in the NN model were optimized to accurately predict the tablet physical properties. The constructed NN model successfully demonstrated the predictive capability with the R2 of ca. 0.9 in both training and validation. The effects of the granulation operating conditions and the tableting pressure on the tablet physical properties were investigated. It was found that the tableting pressure was the most dominant factor for the tablet hardness and disintegration time. Among the granulation operating conditions, liquid solid ratio had the strongest impact on the tablet physical properties. Focusing on the tableting pressure and liquid solid ratio, the contour maps for the relationships between the operating conditions and the tablet physical properties were obtained by the NN model. It was suggested that the obtained contour maps can be helpful to predict the continuous manufacturing of tablets with the desired tablet physical properties.

著者

竹内 寛久 仲村 英也 綿野 哲

出版者

The Society of Powder Technology, Japan

雑誌

粉体工学会誌 (ISSN:03866157)

巻号頁・発行日

vol.49, no.3, pp.191-200, 2012-03-10 (Released:2012-03-22)

参考文献数

21

被引用文献数

2 1

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Numerical modeling of individual particle motion and fluid flow in an impact pulverizer was conducted using a Computational Fluid Dynamics (CFD) - Discrete Phase Model (DPM) coupling model. The impact pulverizer consists of high-speed rotating hammers and a static concavo-convex stator. Influences of the rotor geometries on particle impacts against stator walls were investigated. It was found that particles in the impact pulverizer were accelerated by the fluid drag force caused by the rotating hammers but not by the impact force from the hammers, resulting in impacts against walls of the static stator. Velocities and frequencies of the impacts between particles and walls of the static stator were analyzed under various number of hammers and clearances. As the number of hammers increased, the velocity and frequency increased because velocity of the fluid in circumference of the grinding chamber increased. The number of particle impacts against walls of the static stator decreased with an increase in the clearance. The impact energy which was calculated from the velocity and frequency of the particle impacts has the similar tendency with the experimental ones.