著者

佐藤 有道

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.14, pp.457-461, 1958

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The relationship between the autonomic nervous center and stress in thiamine metabolism in the organs were observed. 1) In rabbits the stimulation of sympathetic center in the hypothalamus caused a considerable decrease of total thiamine concentration in the liver (-61%) and kidney (-68%) after one hour and recovery after 24 hours. The cold stimulation caused a decrease of total thiamine in the liver after one hour (-38%) but a considerable decrease after 24 hours (-54%). Likewise the cold stimulation caused a decrease in the kidney after one hour (-27%) but a considerable decrease after 24 hours (-53%). 2) Simultaneous administration of Chlorpromazine suppressed the decrease due to stimulation. 3) Subcutaneous injection of Chlorpromazine did not show any influence in thiamine concentration, except for a slight decrease in the liver and kidney after one hour.

著者

佐藤 有道

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.14, pp.462-469, 1958

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Changes in thiamine concentration in the liver and kidneys were observed when the left ganglion caeliacum was stimulated by two different methods. 1) In rabbits a sham operation caused a decrease of total thiamine concentration in the liver (25-30%) and in the kidneys (27-36%). 2) The pharmacological stimulation by lead acetate and electric stimulation similarly caused a considerable decrease of total thiamine concentration in liver and kidneys after 1-12 hours (35-46%) . 3) Subcutaneous injection of Chlorpromazine suppressed the decrease due to sham operation and sympathetic stimulation. 4) The participation of the autonomic nervous system and pituitary adrenal system in thiamine metabolism was suggested by the above results.