著者

大門 貴志

出版者

日本計量生物学会

雑誌

計量生物学 (ISSN:09184430)

巻号頁・発行日

vol.33, no.1, pp.1-29, 2012-08-31 (Released:2012-10-02)

参考文献数

145

被引用文献数

2

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A number of designs of phase I dose-finding trials have been developed. Algorithm-based designs such as standard 3 + 3 designs are easy to understand and implement since they do not require explicit model specification for a dose-toxicity relationship. On the other hand, model-based designs such as the continual reassessment method (CRM) (O’Quigley et al., 1990) have been proposed. The author will give a review of the CRM and its related topics. In particular, the author makes mention of some of the problems with 3 + 3 designs that have often been used in phase I dose-finding studies and gives a detailed description of ideas, concepts, theories, properties and issues in the CRM.