著者

浜名 政和 山崎 企善

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.11, no.4, pp.411-414, 1963-04-25 (Released:2008-03-31)

被引用文献数

6 11

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While quinoline 1-oxide itself is not capable to react with acetyl cyanide, an exothermic reaction occurred in the presence of acetic anhydride, and quinaldonitrile and 2-quinolinepyruvonitrile were obtained. The former was a sole product from the reaction in dioxane or chloroform, whereas the latter was the main product without solvent.

著者

後藤 良宣 山崎 企善 浜名 政和

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.19, no.10, pp.2050-2057, 1971-10-25 (Released:2008-03-31)

被引用文献数

15 23

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Six kinds of 2-aryloxazole N-oxide derivatives were prepared, and their reactions with phosphoryl chloride and acetic anhydride were studied. Methyl group located on the 4-position of 2-aryloxazole N-oxide was easily subjective to nucleophilic attack as an active methyl group in the reaction with phosphoryl chloride or acetic anhydride, whereas 5-methyl group was inert to such an attack.

著者

浜名 政和 山崎 企善

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.10, no.1, pp.51-54, 1962-01-25 (Released:2008-03-31)

被引用文献数

7 11

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Alkaline ferricyanide oxidation of some aromatic N-oxides was examined. Quinoline 1-oxide, lepidine 1-oxide, and isoquinoline 2-oxide were smoothly oxidized to the corresponding N-hydroxy-carbostyrils or-isocarbostyrils. From quinaldine 1-oxide, only a small amount of quinaldinic acid 1-oxide was obtained. In contrast, pyridine and nicotinic acid 1-oxide were not affected by this oxidation procedure.

著者

浜名 政和 山崎 企善

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.11, no.4, pp.415-421, 1963-04-25 (Released:2008-03-31)

被引用文献数

21 31

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Quinoline 1-oxides were found to react smoothly with compounds containing reactive hydrogens in the presence of acetic anhydride, producing the corresponding 2-substituted quinolines. The yields were generally good to excellent in the reactions of ethyl cyanoacetate, 1, 3-indandione, diethyl malonate, diethyl nitromalonate, ethyl nitroacetate (e. g. ethyl α-cyano-2-quinolineacetate in 88% yield), but acetone, acetophenone or phenylacetonitrile could not enter into the reaction. The reaction of quinoline 1-oxide using benzoyl chloride instead of acetic anhydride and those of pyridine 1-oxides in the presence of acetic anhydride proceeded similarly but in much lower yields.