著者

日本膵・膵島移植研究会膵島移植班

出版者

一般社団法人 日本移植学会

雑誌

移植 (ISSN:05787947)

巻号頁・発行日

vol.49, no.2-3, pp.292-297, 2014-06-10 (Released:2014-07-18)

参考文献数

6

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Islet transplantation can relieve glucose instability and problems with hypoglycemia while the graft is functioning. However, the long-term results of islet transplantation pointed to the need for progress improving islet graft function. We started the phase II clinical trial with type 1 diabetes patients for islet transplantation using both brain-dead donors and DCD to evaluate ATG induction and TNF inhibition protocol. Primary endpoints are the proportion of subjects with HbA1c<7.4% and who are free of severe hypoglycemic events one years after the first islet cell infusion. This trial would play a critical role in establishing islet transplantation in Japan.