- 著者
- 中島 松一 小野 史郎 林 宏仁
- 出版者
- The Japanese Cancer Association
- 雑誌
- GANN Japanese Journal of Cancer Research (ISSN:0016450X)
- 巻号頁・発行日
- vol.65, no.5, pp.411-416, 1974-10-31 (Released:2008-10-23)
- 参考文献数
- 25
Both humoral and cell-mediated immunity were suppressed by four intravenous injections of 100μg each of 4-hydroxyaminoquinoline 1-oxide, employing bacterial α-amylase and picryl chloride as antigens. Preimmunization of mice with diazotized 4-aminoquinoline 1-oxide-conjugated rabbit serum protein by the use of complete Freund's adjuvant prevented immunosuppression by 4-hydroxyaminoquinoline 1-oxide. Anti-hapten titers of these mice were 25 to 28 estimated by passive hemagglutination during the course of the experiments. Passive immunization by transfer of the specific anti-hapten antibody induced prevention from immunosuppression by the reagent. Therefore, it was suggested that the humoral anti-hapten antibody might play an important role in preventing mice from immunosuppression by the reagent by preimmunization with the hapten-carrier conjugate.