著者

林清 五郎 植木 寛 植木 洋子

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.54, no.4, pp.381-390, 1963-12-31 (Released:2008-10-23)

参考文献数

14

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The antitumor activities of 4, 5-bis(ethyleneimino)-1, 2-benzoquinone (OBE), 2, 5-bis(ethyleneimino)-1, 4-benzoquinone (PBE), and 4-ethyleneimino-1, 2-naphthoquinone (NQE) were investigated in Ehrlich carcinoma. OBE was effective not only in prolonging the life-span of mice bearing Ehrlich ascites carcinoma but also in retarding the growth of the solid form of the same tumor. This compound was proved to be effective even in a smaller dose than the minimum effective dose of PBE, with lower toxicity than the latter. With NQE, the mice bearing the same ascites tumor did not survive longer than the control.Ratio of the number of neutrophils to lymphocytes (N/L) in the peripheral blood was compared with the non-treated and the treated groups of animal bearing the tumor. Generally speaking, the more progressed the growth of the ascites tumor was, the greater the value of N/L, but such increase of N/L was eventually observed in case of leucopenia induced by these agents. It may therefore be said that the observation of change of N/L should be considered as an element for evaluation of the result of screening experiment.