- 著者
-
瀬沼 勝
柴崎 昌隆
西本 茂
柴田 恵次郎
岡村 公生
伊達 忠正
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Chem. Pharm. Bull. (ISSN:00092363)
- 巻号頁・発行日
- vol.37, pp.3204-3208, 1989
- 被引用文献数
-
1
Practical resolution of (2RS, 3RS)-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)propionic acid (2) was examined by the use of several basic amino acids. L-Lysine was found to be the most effective resolving agent to obtain (+)-(2S, 3S)-2,a key intermediate for the synthesis of diltiazem (1). This new method should be applicable to the industrial production of 1 in view of the simplicity of the procedure, the ready availability of L-lysine, and the high yield of the desired isomer. The absolute stereochemistry of (+)-2 was determined to be 2S, 3S by X-ray crystallographic analysis.