著者

菅原 努 永田 弘治 西田 寿男 Sugawara Tsutomu Nagata Hiroji Nishida Hisao スガワラ ツトム ナガタ ヒロジ ニシダ ヒサオ

出版者

日本医学放射線学会

雑誌

日本医学放射線学会雑誌 (ISSN:00480428)

巻号頁・発行日

vol.23, no.2, pp.216-220, 1963-05-25

著者

永田 弘治 菅原 努 田中 富蔵

出版者

日本放射線影響学会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.13, no.3, pp.163-166, 1972-09

被引用文献数

1 31

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A new sulfhydryl compound, 2-mercaptopropionylglycine, which is commercially available in Japan as a detoxicating agent, has been shown to be protective in mice against lethal doses of ionizing radiation at a very low dose of 20 mg/kg, far below its toxic dose of more than 2,000 mg/kg. The drug has an optimum dose for protection, 20 mg/kg, and its protection continues more than 3 hours, though with a less extent after 1 hour than within 1 hour. The results suggest a clue on the mechanism of sulfhydryl radioprotectors and give promise of clinical application.