著者

安井 真人 池内 真志 生田 幸士

出版者

一般社団法人 日本機械学会

雑誌

ロボティクス・メカトロニクス講演会講演概要集

巻号頁・発行日

vol.2011, pp._1A2-H09_1-_1A2-H09_4, 2011

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When a magnetic micro-screw moves in water, it is difficult to go up and to control a magnetic microscrew three-dimensionally because of gravity. Therefore, it is important to control density of a microscrew. Therefore, we have developed magnetically photo-curable (MPC) polymer with hollow microcapsules. This polymer enables us to fabricate a three-dimensional magnetic microstructure whose density is controlled. Since we can control density of this resin, buoyancy of microstructure is able to cancel the effect of gravity. To show neutral buoyancy of the magnetic microscrew, we compared vertical swimming velocity of the microscrew with horizontal velocity. This experimental result shows that vertical velocity coincides with horizontal velocity. This result demonstrates that we have succeeded in fabricating a magnetic microscrew and controlling the microscrew three-dimensionally in water.

著者

池内 真志 生田 幸士

出版者

Japanese Society for Medical and Biological Engineering

雑誌

生体医工学 (ISSN:1347443X)

巻号頁・発行日

vol.43, no.4, pp.646-652, 2005

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The authors of this letter propose a novel "multi-layer hybrid scaffold" consisting of artificial blood capillary networks and cell-containing hydrogel for tissue engineering. The artificial blood capillary network was fabricated using a Membrane Micro Embossing (MeME) process, a unique, newly developed microfabrication process capable of fabricating freestanding thin polymer membrane micro-channels with both simplicity and high precision. With this process, a thin thermoplastic polymer membrane was placed on a deformable support substrate and embossed to fit 3D structures on a master mold by backpressure from the support. A one step heat-sealing method was used to successfully fabricate a highly branched "membrane micro-channel network" of biodegradable poly-lacticacid (PLA) micro-channels measuring 50 μm in width, 50 μm in depth, and 5 μm in wall thickness. The biocompatibility of the fabricated micro-channel was confirmed by culturing human umbilical vascular endothelial cells (HUVEC) on the micro-channel. This technology will provide a useful method for regenerating large organs in the future.