- 著者
- 鴻巣 俊之 田島 和 武田 憲子 宮岡 武男 笠原 真由美 安田 紘 老田 貞男
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.39, no.10, pp.2581-2589, 1991-10-25 (Released:2008-03-31)
- 参考文献数
- 7
- 被引用文献数
- 9 16
New triazole compounds were designed and synthesized as potential inhibitors of the fungal cytochrome P-450 14α-demethylase. In testing for antifungal activity against a mouse systemic Candida albicans infection, (2R, 3R)-3-acylamino-2-aroyl-2-butanol derivatives III exhibited remarkably high efficacy after oral or parenteral administration. The structure-activity relationships of these amidoalcohols were evaluated.