- 著者
- 秋山 稔 大石 順一 白井 孝 明石 景泰 吉田 浩一 錦戸 条二 林 絋 白淵 穣 西村 大吉 伊藤 平隆 渋屋 千征 石田 寅夫
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.26, no.3, pp.981-984, 1978-03-25 (Released:2008-03-31)
- 被引用文献数
- 14 21
In order to obtain 1-β-D-arabinofuranosylcytosine derivatives with better antitumor effect, 12 kinds of saturated fatty acyl groups were introduced at the N4-position of 1-β-D-arabinofuranosylcytosine. The presence of a great excess of water and about two-fold equivalents of carboxylic anhydride was found to be most desirable for selective N4-acylation. This simple method of one-step N4-acylation should be generally applicable to cytosine nucleosides and a variety of carboxylic anhydrides.