著者

KENICHI FUKUI AKIRA IMAMURA CHIKAYOSHI NAGATA

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.51, no.2, pp.119-123, 1960-06-30 (Released:2008-10-23)

参考文献数

20

被引用文献数

1

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The electronic structure of 4-nitroquinoline N-oxide and related compounds were investigated. The frontier electron density and the approximate superdelocalizability for nucleophilic reaction at the carbon atom to which nitro group is attached had a definite correlation with the carcinogenic activity. This is a support for our proposition that the interaction with the nucleophilic center in the body might be primarily concerned with the production of cancer by all types of chemical carcinogens.