- 著者
- Yuichi Saito Hiroyuki Okuyoshi Shinsuke Nakamura Wataru Otsu Akihiro Yamaguchi Peter F. Hitchcock Mikiko Nagashima Masamitsu Shimazawa Hideaki Hara
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- BPB Reports (ISSN:2434432X)
- 巻号頁・発行日
- vol.3, no.3, pp.92-96, 2020 (Released:2020-11-26)
- 参考文献数
- 37
Regenerative medicine aims to replenish damaged tissue. Boosting the capacity of intrinsic stem cells to proliferate is one key for successful regeneration. Adult zebrafish possess tissue resident stem and progenitor cells, which contribute to homeostatic growth and tissue regeneration. In the intact retina, Müller glia sporadically divide to generate fate restricted, proliferative precursors. Cell death reprograms Müller glia into stem cells that divide and produce multi-potent retinal progenitors. Using zebrafish, we evaluated the effect of taurine-conjugated bile acid, Tauroursodeoxycholic acid (TUDCA) on retinal regeneration. In the intact retina, treatment with TUDCA significantly promotes proliferation of the fate restricted precursors, but has no effect on Müller glia. Following constant light exposure, TUDCA attenuates photoreceptor death, indicating that TUDCA is neuroprotective. Following a stab wound, which initiates death of retinal neurons and reprogramming of Müller glia, treatment with TUDCA significantly increases the number of proliferating cells. In the intact retina, TUDCA-induced proliferation was accompanied by decreased expression of cell cycle inhibitors. These results suggest that TUDCA promotes proliferation of actively-cycling stem and progenitors, identifying TUDCA as a potential reagent to promote regeneration of retinal neurons.
- 著者
- Akihiro Yamaguchi Takaaki Seo Keisuke Yoshikawa
- 出版者
- The Japan Society for Industrial and Applied Mathematics
- 雑誌
- JSIAM Letters (ISSN:18830609)
- 巻号頁・発行日
- vol.2, pp.123-126, 2010 (Released:2010-12-10)
- 参考文献数
- 6
- 被引用文献数
- 5 10
In this paper, the pass rate of the NIST SP800-22 statistical test suite for the ideally true random sequences is analyzed by the simulation of statistical tests, and derived by the theoretical analysis under the assumption that there are no correlation among tests. As examples of chaos based system, Vector Stream Cipher (VSC128S) and the encryption system using Arnold's cat map are tested. The test results are compared with the theoretical one for the true random sequences and validity of presented analysis is discussed.