- 著者
- Atsushi Ishimura Yutaka Shimizu Ayano Onishi Naohiro Yabuki Yoshikazu Matsuda
- 出版者
- Japanese Society for Applied Therapeutics
- 雑誌
- アプライド・セラピューティクス (ISSN:18844278)
- 巻号頁・発行日
- vol.18, pp.16-21, 2023 (Released:2023-05-15)
- 参考文献数
- 14
Magnesium oxide, a low-price laxative without a habit-forming tendency after long-term use, is widely used for treating constipation in Japan. However, its use has been associated with hypermagnesemia in patients with impaired magnesium excretion function such as renal insufficiency. Therefore, in this study, we investigated the use of magnesium oxide tablets, which may be administered to the elderly on a long-term basis. We found the total number of prescriptions has increased year by year and exceeded 4 billion tablets in FY 2020. The use and number of prescriptions were highest among individuals in their 80s, and more than 70% of patients taking the drug are aged 70 years or older. Since the elderly experience physiological functional decline, pharmacists must make effective use of not only age but also laboratory data listed on prescriptions when dispensing these medications in order to prevent adverse events.
- 著者
- Atsushi Ishimura Yoshikazu Matsuda
- 出版者
- Japanese Society for Applied Therapeutics
- 雑誌
- アプライド・セラピューティクス (ISSN:18844278)
- 巻号頁・発行日
- vol.17, pp.150-154, 2022 (Released:2022-12-28)
- 参考文献数
- 13
Within Japan, national medical costs are continuing to increase owing to the aging population and advances in medical technologies. The market share occupied by generic drugs is still low compared with other countries. We investigated trends in the use of generic drugs (tablets) with introduced authorized generics (AGs) using National Database of Japan (NDB) Open Data. We evaluated the impact of introducing AGs on the transition to generic drugs. We found that more than 80% of drugs with AGs had generic usage rates exceeding 70%. AGs are often used to treat chronic diseases, such as hypertension. Branded drug manufacturer-approved AGs are considered associated with less negative perceptions; however, despite this, it remains difficult to say whether the introduction of AGs has promoted the use of generic drugs overall. Furthermore, we inferred that the timing of introduction to the market is vital for AGs. Considering the tight medical financial situation in Japan, shifting to the use of generic drugs, including AGs, would be favorable after patents for branded drugs expire. It is also necessary to conduct a detailed analysis of trends in the use of generic drugs, including AGs.