- 著者
- Hiroaki Kikuchi Makoto Aoyagi Kiyotaka Nagahama Yu Yajima Chisato Yamamura Yohei Arai Suguru Hirasawa Shota Aki Naoto Inaba Hiroyuki Tanaka Teiichi Tamura
- 出版者
- 一般社団法人 日本内科学会
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.53, no.11, pp.1131-1135, 2014 (Released:2014-06-01)
- 参考文献数
- 14
- 被引用文献数
- 3 11
A 76-year-old woman with a history of lumbar fracture and marked proteinuria, bilateral pitting edema, malaise and pruritus was referred for an evaluation of an impaired renal function. A renal biopsy led to a tentative diagnosis of acute interstitial nephritis (AIN) with minimal change disease caused by nonsteroidal anti-inflammatory drugs (NSAIDs). Following the discontinuation of oral NSAIDs, the patient's symptoms disappeared spontaneously. However, nephrotic-range proteinuria relapsed one month after discharge, following loxoprofen patch use. The withdrawal of the topical loxoprofen patches once again resulted in the disappearance of all symptoms. This is the first case report of nephrotic-range proteinuria and AIN secondary to topical NSAID patch use.