- 著者
- Tomohiro TAKAKI Kazuya NAKAGAWA Yusuke MORITA Eiji NAKAMACHI
- 出版者
- 一般社団法人日本機械学会
- 雑誌
- Mechanical Engineering Journal (ISSN:21879745)
- 巻号頁・発行日
- vol.2, no.3, pp.15-00063-15-00063, 2015 (Released:2015-06-15)
- 参考文献数
- 61
- 被引用文献数
- 1 6
In this study, we applied a modified Kobayashi-Warren-Carter (KWC) phase-field model to the neurite growth process. To confirm the applicability of this model, we observed axonal extension of PC-12D cells cultured with nerve growth factor (NGF). Based on our observations, we defined three stages of nerve cell axonal extension: neurite generation, neurite contraction, and axon extension. We further determined the parameters in the phase-field equations to express the three extension stages. Finally, our results show that the modified KWC phase-field model reasonably expresses the morphologies of nerve cells and predicts the three stages of nerve cell axonal extension. Although, we employed the binary alloy solidification model as a sample model in the present phase-field simulations, this work will be extensible to relatively more realistic models for nerve cell growth.
- 著者
- Tomohiro TAKAKI Kazuya NAKAGAWA Yusuke MORITA Eiji NAKAMACHI
- 出版者
- 一般社団法人日本機械学会
- 雑誌
- Mechanical Engineering Journal (ISSN:21879745)
- 巻号頁・発行日
- pp.15-00063, (Released:2015-05-22)
- 参考文献数
- 61
- 被引用文献数
- 1 6
In this study, we applied a modified Kobayashi-Warren-Carter (KWC) phase-field model to the neurite growth process. To confirm the applicability of this model, we observed axonal extension of PC-12D cells cultured with nerve growth factor (NGF). Based on our observations, we defined three stages of nerve cell axonal extension: neurite generation, neurite contraction, and axon extension. We further determined the parameters in the phase-field equations to express the three extension stages. Finally, our results show that the modified KWC phase-field model reasonably expresses the morphologies of nerve cells and predicts the three stages of nerve cell axonal extension. Although, we employed the binary alloy solidification model as a sample model in the present phase-field simulations, this work will be extensible to relatively more realistic models for nerve cell growth.