- 著者
-
Hideharu Hagiya
Koji Miyawaki
Norihisa Yamamoto
Hisao Yoshida
Akihiro Kitagawa
Tadafumi Asaoka
Hidetoshi Eguchi
Yukihiro Akeda
Kazunori Tomono
- 出版者
- 一般社団法人 日本内科学会
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.8774-16, (Released:2017-09-25)
- 参考文献数
- 17
- 被引用文献数
-
13
Ceftriaxone is a widely used third-generation cephalosporin showing advantageous pharmacokinetic properties and a broad antimicrobial spectrum. We herein report a case of ceftriaxone-induced neurotoxicity in a 56-year-old man on hemodialysis. Seven days after initiating high-dose ceftriaxone, the patient developed impaired consciousness along with facial myoclonus and sporadic phonation. The symptoms clearly disappeared shortly after withdrawal of the drug. Ceftriaxone is considered a safe antibiotic for patients with renal insufficiency, since it is excreted via both haptic and renal pathways. Physicians should note that antibiotic-associated encephalopathy may develop in patients administered ceftriaxone, especially in those complicated with renal dysfunction.