- 著者
- Hironaka IGARASHI Yuji SUZUKI Vincent J. HUBER Masahiro IDA Tsutomu NAKADA
- 出版者
- Japanese Society for Magnetic Resonance in Medicine
- 雑誌
- Magnetic Resonance in Medical Sciences (ISSN:13473182)
- 巻号頁・発行日
- vol.14, no.1, pp.13-24, 2015-02-01 (Released:2015-02-20)
- 参考文献数
- 93
- 被引用文献数
- 15 23
N-acetylaspartate (NAA) appears in a prominent peak in proton magnetic resonance spectroscopy (1H-MRS) of the brain. Exhibition by NAA of time-dependent attenuation that reflects energy metabolism during the acute stage of cerebral ischemia makes this metabolite a unique biomarker for assessing ischemic stroke. Although magnetic resonance (MR) imaging is a powerful technique for inspecting the pathological changes that occur during ischemic stroke, biomarkers that directly reflect the drastic metabolic changes associated with acute-stage ischemia are strongly warranted for appropriate therapeutic decision-making in daily clinical settings. In this review, we provide a brief overview of NAA metabolism and focus on the use of attenuation in NAA as a means for assessing the pathophysiological changes that occur during the acute stage of ischemic stroke.