著者

Tohru OKADA Tadashi KAMADA Hiroshi TSUJI Jun-etsu MIZOE Masayuki BABA Shingo KATO Shigeru YAMADA Shinji SUGAHARA Shigeo YASUDA Naoyoshi YAMAMOTO Reiko IMAI Azusa HASEGAWA Hiroshi IMADA Hiroki KIYOHARA Kenichi JINGU Makoto SHINOTO Hirohiko TSUJII

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.51, no.4, pp.355-364, 2010 (Released:2010-07-29)

参考文献数

49

被引用文献数

130

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In June 1994, the world's first clinical center offering carbon ion radiotherapy opened at the National Institute of Radiological Science (NIRS), Japan. Among several types of ion species, carbon ions were chosen for cancer therapy because they were judged to have the most optimal properties in terms of superior physical and biological characteristics. As of March 2010, 5,196 patients have been registered for carbon ion radiotherapy. Clinical results have shown that carbon ion radiotherapy has the potential to provide a sufficient radiation dose to the tumor, while having acceptable morbidity in the surrounding normal tissues. Tumors that appear to respond favorably to carbon ions include locally advanced tumors as well as histologically non-squamous cell tumor types such as adenocarcinoma, adenoid cystic carcinoma, malignant melanoma, hepatoma, and bone/soft tissue sarcoma. By taking advantage of the unique properties of carbon ions, treatment with small fractions within a short treatment period has been successfully carried out for a variety of tumors. This means that carbon ion radiotherapy can offer treatment for larger numbers of patients than is possible with other modalities over the same time period.

著者

Komugi Okeya Yukio Kawagishi Emiri Muranaka Toshihide Izumida Hiroshi Tsuji Shinichi Takeda

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.2892-19, (Released:2019-07-22)

参考文献数

14

被引用文献数

9 12

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Hyperprogressive disease (HPD) is a paradoxical phenomenon involving the acceleration of tumor progression after treatment with immune checkpoint inhibitors (ICIs). A 66-year-old male smoker with advanced lung adenocarcinoma started pembrolizumab for progressive disease following first-line chemotherapy. He developed HPD after two cycles, and a re-biopsy revealed transformation to small-cell carcinoma. He subsequently underwent two lines of chemotherapy for small-cell carcinoma until progression and ultimately died. Transformation to small-cell carcinoma may be a cause of HPD during ICI therapy. The possibility of pathological transformation should be considered in cases of HPD with resistance to ICI therapy.

著者

Yuki Ohmoto-Sekine Makiko Ishihara Shiun Dong Hsieh Kazuhisa Amakawa Shigeko Hara Hiroshi Tsuji Rieko Ishimura Sugao Ishiwata Tetsu Yamaguchi Minoru Ohno Yasuji Arase

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.52, no.9, pp.977-980, 2013 (Released:2013-05-01)

参考文献数

16

被引用文献数

4 6

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Kawasaki disease (KD) is one of the most important causes of coronary artery aneurysms in children and young adults. However, the natural course of the disease and the patient prognosis remain obscure. A 72-year-old asymptomatic man with undiagnosed KD underwent whole-heart magnetic resonance coronary angiography during a health checkup. The imaging disclosed giant aneurysms in the proximal portion of the right coronary artery and the left anterior descending artery. The patient was successfully treated with coronary artery bypass grafting. The present case suggests that there may be a substantial number of patients who have attained middle to old age with undiagnosed KD.