- 著者
-
Mayuri ICHINOSE
Katsuyoshi TOJO
Koji NAKAMURA
Hiroyuki MATSUDA
Goro TOKUDOME
Makoto OHTA
Soichi SAKAI
Osamu SAKAI
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.35, no.6, pp.482-488, 1996 (Released:2006-03-27)
- 参考文献数
- 34
- 被引用文献数
-
6
6
A 31-year-old man who had been under regular hemodialysis for 6 months was diagnosed as Williams syndrome (WS) by fluorescence in situ hybridization (FISH) chromosomal analysis. The association of WS and chronic renal failure (CRF) is only rarely encountered. Endocrinological examinations revealed hypergonadotropic hypogonadism. Prolonged and exaggerated responses of adrenocorticotropin (ACTH) to insulin-induced hypoglycemia and corticotropin releasing hormone (CRH) were also noted. While most of the endocrinological abnormalities observed in this patient could be attributed to altered endocrine circumstances in CRF, some findings stand in contrast. Furthermore, the testicular biopsy specimen showed severe hypospermatogenesis. Endocrine disorders observed in this patient may be at least in part, responsible for various clinical features underlying WS.(Internal Medicine 35: 482-488, 1996)