- 著者
- Jie Guo Yang Yao
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.39, pp.22-31, 2012-10-30 (Released:2017-06-01)
- 参考文献数
- 35
The scandal of melamine-contamination has not ended yet, the toxification of melamine continues to raise concerns for public health. It has been well known that fetus and infant periods play the most important role in brain development, then what effect on earth of melamine in children's center nervous system? In the present study, we investigated the effects of melamine (5×10^<-5>g/ml) on GABAergic synaptic activity, which reflecting the basal neurotransmission, in infant rat hippocampal CA1 neurons. The results showed that melamine significantly decreased the amplitude of miniature IPSCs (mIPSCs) without altering spontaneous IPSCs (sIPSCs), illustrating a postsynaptic mechanism of melamine actions on GABAergic synaptic transmission. These results suggested that melamine could alter GABAergic synaptic activity in infant rats, and further damaged the function of learning and memory.