- 著者
- Takashi Kohno Jing Li Kazuyuki Aihara
- 出版者
- 一般社団法人 電子情報通信学会
- 雑誌
- Nonlinear Theory and Its Applications, IEICE (ISSN:21854106)
- 巻号頁・発行日
- vol.5, no.3, pp.379-390, 2014 (Released:2014-07-01)
- 参考文献数
- 39
- 被引用文献数
- 2 8
Neuromorphic systems are designed by mimicking or being inspired by the nervous system, which realizes robust, autonomous, and power-efficient information processing by highly parallel architecture. It is a candidate of the next-generation computing system that is expected to have advanced information processing ability by power-efficient and parallel architecture. A silicon neuronal network is a neuromorphic system with a most detailed level of analogy to the nervous system. It is a network of silicon neurons connected via silicon synapses;they are electronic circuits to reproduce the electrophysiological activity of neuronal cells and synapses, respectively. There is a trade-off between the proximity to the neuronal and synaptic activities and simplicity and power-consumption of the circuit. Power-efficient and simple silicon neurons assume uniform spikes, but biophysical experimental data suggest the possibility that variety of spikes given to a synapse is playing a certain role in the information processing in the brain. In this article, we review our design approach of silicon neuronal networks where uniform spikes are not assumed. Simplicity of the circuits is brought by mathematical techniques of qualitative neuronal modeling. Though it is neither simpler nor low-power consuming than above silicon neurons, it is expected to be more appropriate for silicon neuronal networks applied to brain-morphic computing.
- 著者
- Xiao-cong ZUO Ya-nan ZHOU Bi-kui ZHANG Guo-ping YANG Ze-neng CHENG Hong YUAN Dong-sheng OUYANG Shi-kun LIU Jeffrey S. BARRETT Pei-jiong LI Zhi LIU Hong-yi TAN Ren GUO Ling-yun ZHOU Yue-liang XIE Zuo-jun LI Jing LI Chun-jiang WANG Jiang-lin WANG
- 出版者
- The Japanese Society for the Study of Xenobiotics
- 雑誌
- Drug Metabolism and Pharmacokinetics (ISSN:13474367)
- 巻号頁・発行日
- vol.28, no.5, pp.398-405, 2013 (Released:2013-10-25)
- 参考文献数
- 51
- 被引用文献数
- 19
The objective of this study was to evaluate the effect of the CYP3A5*3 allele on the pharmacokinetics of tacrolimus and amlodipine, and drug-drug interactions between them in healthy subjects. Pharmacokinetic drug interactions between tacrolimus and amlodipine were evaluated in a randomized, 3-period, 6-sequence crossover study in healthy Chinese volunteers according to CYP3A5 genotype. A single-dose and multiple-dose study were designed. A 96-h pharmacokinetic study followed either tacrolimus or amlodipine dose, and the washout periods between the study phases were 14 days. In the single-dose study, apparent oral clearance (CL/F) of tacrolimus (5 mg) in CYP3A5 expressers was 3.8-fold (p = 0.008) higher than that in CYP3A5 non-expressers. Amlodipine decreased mean tacrolimus CL/F in CYP3A5 expressers by 2.2-fold (p = 0.005), while it had no effect on that in CYP3A5 non-expressers. The CL/F of amlodipine in CYP3A5 non-expressers was 2.0-fold (p = 0.001) higher than that in CYP3A5 expressers. Tacrolimus increased mean amlodipine CL/F in CYP3A5 expressers by 1.4-fold (p = 0.016) while it had no effect on that in CYP3A5 non-expressers. Tacrolimus slightly reduced the AUC0–∞ of amlodipine in both CYP3A5 expressers and non-expressers. Dose adjustment of tacrolimus should be considered according to CYP3A5*3 genetic polymorphism when tacrolimus is coadministered with amlodipine.