- 著者
- Eun-Joo Shin Jae-Hyung Bach Sung Youl Lee Jeong Min Kim Jinhwa Lee Jau-Shyong Hong Toshitaka Nabeshima Hyoung-Chun Kim
- 出版者
- (公社)日本薬理学会
- 雑誌
- Journal of Pharmacological Sciences (ISSN:13478613)
- 巻号頁・発行日
- vol.116, no.2, pp.137-148, 2011 (Released:2011-06-16)
- 参考文献数
- 100
- 被引用文献数
- 11 28
Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.