- 著者
- Surat Laphookhieo John Keith Syers Rattana Kiattansakul Kan Chantrapromma
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.54, no.5, pp.745-747, 2006 (Released:2006-05-01)
- 参考文献数
- 12
- 被引用文献数
- 40 64
A new prenylated xanthone, 5-O-methylcelebixanthone (1), together with six known compounds; celebixanthone (2), 1,3,7-trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone (3), cochinchinone A (4), α-mangostin (5), β-mangostin (6) and cochinchinone C (7) were isolated from roots of Cratoxylum cochinchinense. Their structures were elucidated by spectroscopic methods. Compounds 2 and 4—7 showed cytotoxic activity against the human lung cancer cell line (NCI-H187) with IC50 values ranging from 0.65 to 5.2 μg/ml. Compounds 1, 2, 6 and 7 also showed antimalarial activity against Plasmodium falciparum with IC50 values of 3.2, 4.9, 7.2 and 2.6 μg/ml, respectively.