- 著者
- Keerthi S. Guruge Hirokazu Hikono Nobuaki Shimada Kenji Murakami Jun Hasegawa Leo W.Y. Yeung Noriko Yamanaka Nobuyoshi Yamashita
- 出版者
- The Japanese Society of Toxicology
- 雑誌
- The Journal of Toxicological Sciences (ISSN:03881350)
- 巻号頁・発行日
- vol.34, no.6, pp.687-691, 2009-12-01 (Released:2009-12-01)
- 参考文献数
- 14
- 被引用文献数
- 51 72
Recent studies showed that perfluorooctane sulfonate (PFOS) affects the mammalian immune system at levels reportedly found in the general human population. It has been demonstrated that exposure to immunotoxic chemicals may diminish the host resistance of animals to various pathogenic challenges and enhance mortality. Therefore, the current study was carried out to characterize the effect of a 21 day pre-administration of zero, 5, or 25 μg PFOS/kg bw/day in female B6C3F1 mice on host resistance to influenza A virus infection. At the end of PFOS exposure, body/organ weights did not significantly change whereas PFOS distribution in blood plasma, spleen, thymus and lung was dose-dependently increased. PFOS exposure in mice resulted a significant increase in emaciation and mortality in response to influenza A virus. The effective plasma concentrations in female mice were at least several fold lower than reported mean blood PFOS levels from occupationally exposed humans, and fell in the upper range of blood concentrations of PFOS in the normal human population and in a wide range of wild animals. Hence, it should be important to clarify the precise mechanism(s) for excess mortality observed in the high dose group.
- 著者
- Kei TAKAKURA Takayuki SAKO Haruo MIYADERA Kenichi YOSHIOKA Yoshiji KARINO Kohichi NAKAYAMA Tsukasa SUGITA Daisuke UEMATSU Kohei OKUTOMO Jun HASEGAWA Toshiyuki KOHNO Eiki HOTTA
- 出版者
- The Japan Society of Plasma Science and Nuclear Fusion Research
- 雑誌
- Plasma and Fusion Research (ISSN:18806821)
- 巻号頁・発行日
- vol.13, pp.2406075, 2018-06-12 (Released:2018-08-22)
- 参考文献数
- 9
- 被引用文献数
- 5
Feasibility studies on neutron radiography using an inertial electrostatic confinement (IEC) neutron source were carried out. A Monte Carlo analysis was carried out to evaluate the feasibility of neutron radiography experiment. Imaging tests using a medium-sized IEC neutron source were conducted with the indirect method using a dysprosium (Dy) foil and an imaging plate. Neutron images of objects consisting of six Cd pins and an array of B4C powder contained in a stainless-steel blade were obtained. The numerical and experimental results confirmed that the IEC neutron source can be applied to neutron radiography even with relatively low neutron flux of ∼102 n/s/cm2.