著者
Kanae Yasumatsu Jun-ichi Nagao Ken-ichi Arita-Morioka Yuka Narita Sonoko Tasaki Keita Toyoda Shoko Ito Hirofumi Kido Yoshihiko Tanaka
出版者
Japanese Association for Laboratory Animal Science
雑誌
Experimental Animals (ISSN:13411357)
巻号頁・発行日
vol.69, no.2, pp.250-260, 2020 (Released:2020-04-24)
参考文献数
33
被引用文献数
15

Maternal immune activation (MIA) by an infection is considered to be an important environmental factor of fetal brain development. Recent animal model on MIA induced by polyinosinic:polycytidylic acid, a mimic of viral infection, demonstrates that maternal IL-17A signaling is required for the development of autism spectrum disorder (ASD)-like behaviors of offspring. However, there is little information on bacterial infection. In this study, we aim to elucidate the influence of MIA induced by lipopolysaccharide (LPS) to mimic a bacterial infection on fetal brain development. We demonstrated that LPS-induced MIA promoted ASD-like behaviors in mouse offspring. We further found that LPS exposure induced acute phase immune response: elevation of serum IL-17A levels in MIA mothers, upregulation of Il17a mRNA expression and increase of IL-17A-producing γδ T cells in the uterus, and upregulation of Il17ra mRNA expression in the fetal brain. Blocking of IL-17A in LPS-induced MIA ameliorated ASD-like behaviors in offspring. Our data suggest that bacterial-induced maternal IL-17A pathway promotes ASD-like behaviors in offspring.