- 著者
- Katsuhiro KONNO Katsuji OJIMA Takaaki HAYASHI Miyuki TANABE Hiroaki TAKAYAMA
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.45, no.1, pp.185-188, 1997-01-15 (Released:2008-03-31)
- 参考文献数
- 15
- 被引用文献数
- 4 6
Synthesis of a 1α, 25-dihydroxyvitamin D2 analog (3), in which the double bond in the side-chain in replaced by an amide group, is described. Condensation of a carboxylic acid (8) with an amine (6) gave an amide (9), which in turn led to 3 via several steps. The analog (3) could not bind to the chick cytosol vitamin D receptor, which indicated the importance of the hydrophobic interaction of the C(22)-C(23) double bond in 1α, 25-dihydroxyvitamin D2 (2) with the vitamin D receptor.