- 著者
- Hiroaki Okada Manabu Wada Hiroyasu Sato Yoshitaka Yamaguchi Haruko Tanji Katsuro Kurokawa Toru Kawanami Toshiyuki Takahashi Takeo Kato
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.52, no.23, pp.2665-2668, 2013 (Released:2013-12-01)
- 参考文献数
- 16
- 被引用文献数
- 6 19
We report the case of a 48-year-old woman presenting with an elevated serum creatine kinase level (hyperCKemia) associated with an initial attack of neuromyelitis optica (NMO). The patient initially showed general fatigue with fever. Laboratory findings showed hyperCKemia and subsequently she developed a slight weakness of both lower limbs and reduced vision. Autoantibodies against aquaporin 4 were found in her serum, and a retrospective examination of viral titers indicated a possible coxsackie virus group A10 infection. The present case suggests that hyperCKemia-mediated disease onset is involved in some patients with NMO, and furthermore, it may be related to muscular destruction associated with viral infection.