- 著者
- Shinichi MEGURO Tomohito MIZUNO Kouji ONIZAWA Keiko KAWASAKI Hideaki NAKAGIRI Yumiko KOMINE Junko SUZUKI Yuji MATSUI Tadashi HASE Ichiro TOKIMITSU Hiroyuki SHIMASAKI Hiroshige ITAKURA
- 出版者
- Japan Oil Chemists' Society
- 雑誌
- Journal of Oleo Science (ISSN:13458957)
- 巻号頁・発行日
- vol.50, no.7, pp.593-598, 2001 (Released:2002-06-28)
- 参考文献数
- 29
- 被引用文献数
- 14 16 17
Examination was made of the effects of tea catechins (TC) on diet-induced obesity. Exposure to high-fat-diet (30% fat) in C57BL/6J mice for 4 weeks induced significant increase in body weight, visceral fat (epididymal, mesenteric, retroperitoneal, perinephric) weight and plasma concentrations of glucose, triacylglycerol and leptin, compared to low-fat diet (5% fat). Treatment with 0.1%TC (high-fat diet +0.1%TC group) had little effect on diet-induced obesity. Relative to high-fat diet and 0.1%TC treatment, 0.5%TC treatment (high-fat diet +0.5%TC group) was noted to bring about significant decrease in body weight, visceral, fat weights and plasma leptin. Lipid absorption rate was the same with the high fat diet and 0.5%TC treatment. An oral soluble starch and sucrose (SS-S) tolerance test was conducted on C57BL/6J mice to evaluate the effects of TC to sugar absorption. When the ratio of TC to sum of SS-S was the same as that in the diet composition for the 0.5%TC treatment, the plasma glucose level showed no response. These results demonstrate for the first time TC to have antiobesity effects on diet-induced obesity in mice, and suggest these effects to be exerted through a mechanism that would not involve inhibition of intestinal absorption of sugar and lipid.