- 著者
- Daxin LI Kengo SHIGETOMI Shinya MITSUHASHI Makoto UBUKATA
- 出版者
- (社)日本農芸化学会
- 雑誌
- Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)
- 巻号頁・発行日
- vol.77, no.12, pp.2499-2501, 2013-12-23 (Released:2013-12-23)
- 参考文献数
- 15
- 被引用文献数
- 2
Maillard reaction inhibitors could be useful therapeutics for diabetes and other age-related diseases. We isolated for the first time 4-O-demethylsilvaticol (1) and (−)-mitorubrin (2) as Maillard reaction inhibitors from Paecilomyces sp. 3193B. Among the isolated inhibitors, 2 showed most potent inhibitory effect by an SDS–PAGE assay on cross-linked protein formation and by a fluorescent assay on AGE formation.