- 著者
- Tomonori Ozeki Naotaka Ogasawara Shinya Izawa Mari Mizuno Kenichiro Yanamoto Hisatsugu Noda Noriko Okaniwa Atsushi Tanabe Makoto Sasaki Kunio Kasugai
- 出版者
- 一般社団法人 日本内科学会
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.52, no.11, pp.1183-1187, 2013 (Released:2013-06-01)
- 参考文献数
- 15
- 被引用文献数
- 4 10
A 63-year-old woman was admitted with symptoms of watery diarrhea and generalized edema lasting for five months. She had been administered 15 mg/day of lansoprazole. Laboratory findings revealed severe hypoproteinemia with normal liver, renal, thyroid and adrenal functions and no proteinuria. Colonoscopy revealed edematous mucosa, minor diminished vascular transparency and apparent longitudinal linear lacerations. The histopathological findings were compatible with a diagnosis of collagenous colitis (CC). Protein leakage from the colon was identified on 99mTc-human serum albumin scintigraphy. The results indicated CC associated with protein-losing enteropathy. Discontinuing lansoprazole ameliorated the watery diarrhea and generalized edema, increased the serum albumin level and improved the hypoproteinemia.