- 著者
- Takeshi Takata Akihisa Kataoka Ayaka Yanagawa Kenshiro Shiraishi Jun’ichi Kotoku
- 出版者
- Japan Transcatheter Valve Therapies
- 雑誌
- Journal of Transcatheter Valve Therapies (ISSN:24344532)
- 巻号頁・発行日
- vol.5, no.1, pp.17-23, 2023 (Released:2023-07-19)
- 参考文献数
- 15
Objective: Recently, the number of structural heart disease (SHD) procedures has increased, leading to increased radiation exposure doses of physicians. Information about SHD physicians’ exposure is insufficient to elucidate their degree of exposure. Physicians’ radioprotection is therefore poor or sometimes overly cautious. This study uses quantitative evaluation with a physical simulation to elucidate the exposure dose sustained by physicians during SHD procedures.Methods: The reported Monte Carlo system was used for dose estimation while using statistical sampling to simulate particle interactions in matter. The simulation geometry resembled an actual SHD procedure. Body models were posturally transformed to simulate a physician’s posture for the procedure faithfully and correctly.Results: Doses for the left eye lens in the upper body were about 1.5 times higher than doses for the right eye lens under all fluoroscopic directions. Doses for the left-hand skin were twice those for the right side. Hand skin doses varied depending on the direction. The same applied to doses for abdominal skin.Conclusion: The results of this study suggest that physicians’ exposures differ significantly depending on the fluoroscopic directions. Physicians should understand the dose differences and endeavor to reduce risks posed by self-exposure.
- 著者
- Nakashi SASANO Atsushi ENOMOTO Yoshio HOSOI Yosuke KATSUMURA Yoshihisa MATSUMOTO Kenshiro SHIRAISHI Kiyoshi MIYAGAWA Hiroshi IGAKI Keiichi NAKAGAWA
- 出版者
- Journal of Radiation Research Editorial Committee
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.48, no.6, pp.495-503, 2007 (Released:2007-11-21)
- 参考文献数
- 58
- 被引用文献数
- 20
Edaravone, a clinical drug used widely for the treatment of acute cerebral infarction, is reported to scavenge free radicals. In the present study, we investigated the radioprotective effect of edaravone on X-ray-induced apoptosis in MOLT-4 cells. Apoptosis was determined by the dye exclusion test, Annexin V binding assay, cleavage of caspase, and DNA fragmentation. We found that edaravone significantly suppressed the X-ray-induced apoptosis. The amount of intracellular ROS production was determined by the chloromethyl-2',7'-dichlorodihydro-fluorescein diacetate system. We found that the intracellular ROS production by X-irradiation was completely suppressed by the addition of edaravone. The accumulation and phosphorylation of p53 and the expression of p21WAF1, a target protein of p53, which were induced by X-irradiation, were also suppressed by adding edaravone. We conclude that the free radical scavenger edaravone suppresses X-ray-induced apoptosis in MOLT-4 cells by inhibiting p53.