著者

Sato Jun J. Ohdachi Satoshi D. Echenique-Diaz Lazaro M. Borroto-Páez Rafael Begué-Quiala Gerardo Delgado-Labañino Jorge L. Gámez-Díez Jorgelino Alvarez-Lemus José Nguyen Son Truong Yamaguchi Nobuyuki Kita Masaki

出版者

Nature Publishing Group

雑誌

Scientific Reports (ISSN:20452322)

巻号頁・発行日

vol.6, pp.31173, 2016-08-23

被引用文献数

30

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The Cuban solenodon (Solenodon cubanus) is one of the most enigmatic mammals and is an extremely rare species with a distribution limited to a small part of the island of Cuba. Despite its rarity, in 2012 seven individuals of S. cubanus were captured and sampled successfully for DNA analysis, providing new insights into the evolutionary origin of this species and into the origins of the Caribbean fauna, which remain controversial. We conducted molecular phylogenetic analyses of five nuclear genes (Apob, Atp7a, Bdnf, Brca1 and Rag1; total, 4,602 bp) from 35 species of the mammalian order Eulipotyphla. Based on Bayesian relaxed molecular clock analyses, the family Solenodontidae diverged from other eulipotyphlan in the Paleocene, after the bolide impact on the Yucatan Peninsula, and S. cubanus diverged from the Hispaniolan solenodon (S. paradoxus) in the Early Pliocene. The strikingly recent divergence time estimates suggest that S. cubanus and its ancestral lineage originated via over-water dispersal rather than vicariance events, as had previously been hypothesised.

著者

Echenique-Díaz Lázaro M. OHDACHI Satoshi KITA Masaki Begué-Quiala Gerardo Páez Rafael Borroto Labañino Jorge L. Delgado Díez Jorgelino Gámez HOSON Osamu SAITO Chiemi

出版者

宮城教育大学環境教育実践研究センター

雑誌

環境教育研究紀要 (ISSN:13448005)

巻号頁・発行日

vol.16, pp.89-95, 2014-03

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Assessing local people's knowledge of endangered species is important not only for the planning and implementation of environmental education programs, but also to address community-based conservation issues and guarantee an effective engagement of local residents in conservation efforts. A questionnaire-based study conducted in Alejandro de Humboldt National Park assessed local people’s knowledge of the endangered Cuban Solenodon (Solenodon cubanus). From this it was found that although children seem to be better informed than adults with respect to the Cuban Solenodon, more needs to be done to educate both age and groups alike. This study also highlighted local residents’ positive disposition to actively participate in the Cuban Solenodon conservation effort.

著者

Kita Masaki Oka Hirotaka Usui Akihiro Ishitsuka Tomoya Mogi Yuzo Watanabe Hidekazu

出版者

Elsevier

雑誌

Tetrahedron (ISSN:00404020)

巻号頁・発行日

vol.68, no.42, pp.8753-8760, 2012-10

被引用文献数

7

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Mycalolides are tris-oxazole macrolides isolated from the marine sponge Mycale sp., which shows cytotoxic, antifungal, and actin-depolymerizing activities. To develop an efficient synthetic route of mycalolides and to evaluate its functional mechanism of biological activities, tris-oxazole macrolactone analogs of mycalolides were synthesized through the use of ring-closing metathesis (RCM). The presence/absence of protecting groups at C3, solvent polarity, and reaction temperature significantly affected the stereoselectivity of RCM (E/Z=2.5/1.0–1.0/2.5). The 19E- and 19Z-stereoisomers both exhibited moderate cytotoxicity against tumor cells, but neither showed significant actin-depolymerizing properties or antimycotic activity against pathogenic fungi. Thus, both the side-chain (actin-binding) moiety and the macrolactone moiety were suggested to be essential for the potent biological activities of the parent molecules.