著者

Atsushi OHTSU Koichi GOTO Takayuki YOSHINO

出版者

The Japan Academy

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

pp.pjab.99.015, (Released:2023-08-09)

被引用文献数

2

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Cancer comprehensive genomic profiling (CGP) is a fundamental tool for promoting precision oncology in advanced solid tumors. In 2015, we launched the SCRUM-Japan platform for CGP test screening followed by enrollment in genomically-matched clinical trials. More than 30,000 tissue-based and 10,000 liquid-based CGP tests have already been performed for enrollment in a total of 127 industry-/investigator-initiated registration trials. So far, 12 new agents with 14 indications have achieved regulatory approval for health care coverage in Japan. Using the clinical-genomic database of this project, a new driver gene was recently discovered with a dramatic response to a genomically-matched agent. Liquid biopsies are a potentially powerful tool for establishing precision oncology. Our comparative study with tissue-based CGPs revealed the utility of liquid biopsy in terms of being less invasive, shorter turn-round time, and higher enrollment rate for genotype-matched treatment than tissue-based CGP in gastrointestinal cancers. Another major multilayer multi-omics study (MONSTAR-SCREEN-2) including whole exome/transcriptome tissue- and liquid-based analyses and multiplex immunohistochemistry, with artificial intelligence/machine learning was launched in 2020 for the purpose of novel biomarker and new oncology agent discovery/development in collaboration with 18 pharmaceutical companies.For detecting minimal/molecular residual disease (MRD) after surgery, post-surgical monitoring with tumor-informed liquid biopsy assays in association with two randomized controlled trials also started in 2020 (CIRCULATE-Japan). More than 5,000 patients have already been enrolled and the observational cohort study showed the clear utility of MRD monitoring for predicting recurrence, leading to changes in clinical practice in patient selection regarding who should receive adjuvant therapy in the near future.

著者

Yoshitaka MURONO Koichi GOTO

出版者

Railway Technical Research Institute

雑誌

Quarterly Report of RTRI (ISSN:00339008)

巻号頁・発行日

vol.52, no.4, pp.193-198, 2011 (Released:2011-11-17)

参考文献数

2

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A great earthquake of magnitude M9.0, occurred around 14:46 pm on March 11, 2011, at an epicenter at an undersea depth of 24 km off the Sanriku coast line, an area in the northeastern part of the main island of Japan. The earthquake was named as "2011 off the Pacific Coast of Tohoku Earthquake." A large-scale fault slide occurred at the plate boundary stretching from the offshore area of Iwate to Ibaraki, and caused heavy tremors of level 7 Japanese Seismic Intensity at Kurihara City in Miyagi Prefecture, and of level 6+ in wider areas in Miyagi, Fukushima, Ibaraki and Tochigi prefectures. This article outlines the outline of the earthquake, and gives an overview of RTRI activities to support the recovery of railway networks damaged by the earthquake. The comparisons of the actual shaking waves of this earthquake with design waves in the Design Standards for Railway Structures: Volume of Seismic Design is also described.