- 著者
- Toshikazu Ozeki Rui Kawato Mitsuru Watanabe Shun Minatoguchi Yukari Murai Akihiro Ryuge Koji Takasugi Takuya Hamada Yukako Oyama Atsushi Nomura Tatsuhito Tomino Hideaki Shimizu Yoshiro Fujita
- 出版者
- 一般社団法人 日本内科学会
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.55, no.7, pp.775-778, 2016 (Released:2016-04-01)
- 参考文献数
- 15
- 被引用文献数
- 1 8
A 72-year-old woman with a history of type 2 diabetes mellitus was brought to the ER with metformin-associated lactic acidosis. She received continuous hemofiltration and hemodialysis, but the laboratory analyses showed no improvement. She died 11 hours after admission. Metformin is minimally bound to proteins and is readily dialyzable, but a prolonged period of dialysis is required, because metformin has a very large distribution volume and is distributed to multiple compartments. The peak blood metformin level was 432 mg/L in this case, which is one of the highest metformin concentrations ever reported, and eight hours of hemodialysis were not sufficient to reduce the serum level.