- 著者
- Nobuaki Egashira Ai Nogami Katsunori Iwasaki Ayumi Ishibashi Naoki Uchida Kotaro Takasaki Kenichi Mishima Ryoji Nishimura Ryozo Oishi Michihiro Fujiwara
- 出版者
- The Japanese Pharmacological Society
- 雑誌
- Journal of Pharmacological Sciences (ISSN:13478613)
- 巻号頁・発行日
- vol.116, no.3, pp.316-320, 2011 (Released:2011-07-15)
- 参考文献数
- 15
- 被引用文献数
- 32 34
In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep in group-housed mice. The prolongation of sleeping time by YKS was reversed by bicuculline (3 mg/kg, i.p.) and flumazenil (3 mg/kg, i.p.), but not WAY100635. These findings suggest that the GABAA – benzodiazepine receptor complex, but not 5-HT1A receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation.