著者

Kwon Hak Cheol Jung Chil Mann Shin Cha Gyun LEE Jong Kyo CHOI Sang Un KIM Sun Yeou LEE Kang Ro

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.48, no.11, pp.1796-1798, 2000-11-01

参考文献数

17

被引用文献数

5

---

The phytochemical study of the aerial parts of Aster scaber THUNB. (Asteraceae) yielded a new caffeoyl quinic acid, (-) 3,5-dicaffeoyl-muco-quinic acid (2) and three known compounds, (-) 3,5-dicaffeoyl quinic acid (1), (-) 4,5-dicaffeoyl quinic acid (3), (-) 5-caffeoyl quinic acid (4). The structures were established by high resolution spectroscopic methods. The antiviral effects against HIV-1 integrase of the compounds was evaluated. (-) 3,5-Dicaffeoyl-muco-quinic acid (2) exhibited potent antiviral activity with an IC_<50> value of 7.0±1.3 μg/ml.